Abstract: Disclosed are systems, methods and computer program products for detecting computer malware. In one example, a security server receives information about a suspicious software object detected by a client computer using one or more malware detection methods. The server identifies the malware detection methods used to detect the suspicious object, and selects one or more different malware detection methods to check whether the suspicious object is malicious or clean. The server analyzes the suspicious object using the selected one or more different malware analysis methods to check whether the object is malicious or clean. If the object is determined to be malicious, the server generates and sends to the client computer detection instructions specific to the one or more malware detection methods used by the client computer for detecting and blocking the malicious object on the client computer.