Patents by Inventor SERGI SVITASHEV

SERGI SVITASHEV has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR HOMOLOGY DIRECTED REPAIR OF DOUBLE STRAND BREAKS IN PLANT CELL GENOMES
    Publication number: 20210238614
    Abstract: Methods and compositions are provided for the improvement of homology-directed repair of a double strand break in a plant cell, via the use of a polynucleotide comprising sequences homologous to the target site. In some aspects, the double strand break is created by an RNA-guided Cas endonuclease. The homology-directed repair of the double-strand break may include incorporation of a heterologous polynucleotide, for example a gene encoding a trait of agronomic importance. The homology-directed repair of the double-strand break may occur as a result of template-directed repair using a polynucleotide repair template.
    Type: Application
    Filed: May 7, 2019
    Publication date: August 5, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: AJITH ANAND, WILLIAM JAMES GORDON-KAMM, SANDEEP KUMAR, ZHAN-BIN LIU, SERGI SVITASHEV
  • METHODS AND COMPOSITIONS FOR HOMOLOGY-DIRECTED REPAIR OF CAS ENDONUCLEASE MEDIATED DOUBLE STRAND BREAKS
    Publication number: 20210087573
    Abstract: Compositions and methods are provided for effecting homology-directed repair at the site of a double-strand-break repair in a polynucleotide. In some aspects, the frequency of HDR is improved as compared to a control method. In some aspects, the ratio of HR to NHEJ is increased. In some aspects, the percentage of HR relative to the total number of mutant reads is increased.
    Type: Application
    Filed: May 7, 2019
    Publication date: March 25, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: STEPHEN LAWRENCE GASIOR, SERGI SVITASHEV, JOSHUA K YOUNG