Abstract: The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Abstract: The disclosure relates to displays. In one arrangement a plurality of pixels are provided. Each pixel comprises a first optical element reversibly switchable between at least two optical states, and a second optical element reversibly switchable between at least two optical states. The first optical element overlaps spatially with the second optical element in an overlap region when viewed from a viewing side of the display, such that an overall optical effect for the overlap region is defined by a combination of the optical state of the first optical element and the optical state of the second optical element. Row signal lines and column signal lines allow individual addressing of each pixel by applying a combination of a row control signal and a column control signal to the pixel. A driving controller applies the row control signals and the column control signals to the pixels.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for determining the risk of a subject suffering from chronic kidney disease of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with clinical/biochemical risk factors for CVD as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for the reclassification of a subject to a more appropriate risk assessment to that obtained using the algorithms for such risk estimation such us but not limited to Framingham, Regicor, Score, Procamor Qrisk based on the presence of different polymorphisms. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to a method for a more appropriate thromboembolic event risk assessment based on the presence of different genetic variant. The invention also relates to a method for determining the risk of suffering a thromboembolism disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for thromboembolism as well as computer-implemented means for carrying out said method.

Abstract: The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.

Abstract: The invention relates to a method for determining the risk of suffering a cardiovascular disease based on the presence of different polymorphisms as well as to kits for practicing the above method. The invention also relates to a method for determining the risk of suffering a cardiovascular disease by combining the absence or presence of one or more polymorphic markers in a sample from the subject with conventional risk factors for CVD as well as computer-implemented means for carrying out said method.

Abstract: The invention is directed to a plug valve comprising a body which includes an inlet port, an outlet port and a cavity that is connected between the inlet and outlet ports; first and second seal segments which are mounted in the cavity and which each comprise a through bore that is coaxial with the inlet and outlet ports; the through bores and the inlet and outlet ports defining a flow passage through the body; a plug member which is rotatably positioned between the first and second seal segments and which includes a hole that extends transversely therethrough; the plug member being rotatable between an open position in which the hole is aligned with the flow passage and a closed position in which the hole is offset from the flow passage; and at least a first booster spring which is positioned between the first seal segment and the body to bias the first seal segment against the plug member.

Abstract: The invention is directed to a plug valve comprising a body which includes an inlet port, an outlet port and a cavity that is connected between the inlet and outlet ports; first and second seal segments which are mounted in the cavity and which each comprise a through bore that is coaxial with the inlet and outlet ports; the through bores and the inlet and outlet ports defining a flow passage through the body; a plug member which is rotatably positioned between the first and second seal segments and which includes a hole that extends transversely therethrough; the plug member being rotatable between an open position in which the hole is aligned with the flow passage and a closed position in which the hole is offset from the flow passage; and at least a first booster spring which is positioned between the first seal segment and the body to bias the first seal segment against the plug member.

Abstract: The present invention is directed to a swivel joint for fluid conduits which comprises a central axis; a tubular male member having an outer annular surface, a first end and at least first and second outer annular grooves formed on the outer surface coaxial with the central axis; a tubular female member having an inner annular recess, an annular shoulder formed at an inner end of the recess and at least first and second inner annular grooves formed on the recess coaxial with the central axis; wherein the outer surface of the male member is adapted to be received in the recess of the female member such that the first end is disposed proximate the shoulder and each outer groove is aligned with a corresponding inner groove to thereby define at least first and second annular races; a plurality of balls disposed in each race to secure said male and female members together and to facilitate relative rotation of the male and female members about the central axis; wherein the radius of each race as measured from the

Abstract: A fluid-carrying swivel joint has a stepped bearing race arrangement on interconnecting hubs having an improved bore seal capability. The stepped arrangement allows more ball bearings per adjacent race which allows equal distribution of hydrostatic end loading to each bearing race, thereby enabling maximum total end loading while minimizing load concentration on a particular bearing race section due to increased total ball and race contact area. A straight bore type seal is used to reduce surface area subject to axial pressure and to minimize rotational friction.

Abstract: A bore seal assembly for sealing between first and second adjoining tubular members which comprises a cylindrical seal sleeve having a bore and two radially outwardly extending sealing lips for engaging a seal pocket formed in the adjoining ends of the first and second tubular members, a cylindrical wear sleeve mounted within the bore for supporting the seal sleeve within the seal pocket, and an elongated erosion sleeve extending longitudinally from the wear sleeve into at least the first tubular member, whereby the erosion sleeve protects the first tubular member against erosion.

Abstract: A swivel joint comprises a tubular male member having at least first and second outer annular grooves formed on an outer surface, a tubular female member having at least first and second inner annular grooves formed on an inner recess, and a plurality of balls disposed in at least first and second annular races which are formed by the alignment of the first and second outer grooves with the first and second inner grooves when a first end of the male member is received within the recess of the female member. In addition, the radius of the first race is greater than the radius of an adjacent race closer to the first end of the male member, and the number of balls in the first race is just one more than the number of balls in the adjacent race closer to the first end.