Abstract: A surgical instrument for relieving carpal tunnel syndrome has an elongated member including a first portion for handling and a second portion. The second portion has a first surface, a second surface, and a blade on the first surface. The blade has a trailing edge and a sharp, convex leading edge. The leading edge rises gradually at a first angle with respect to the first surface so that when the leading edge is pushed against tissue to make an incision, damage to the surrounding tissue is reduced. The first angle is less than 90 degrees. In carpal tunnel release surgery, a transverse incision is made in the patient's distal wrist crease with a surgical instrument. The surgical instrument is positioned below the, transverse carpal ligament and advanced in a closed procedure towards the patent's fingertips until the transverse carpal ligament is completely transected.