Patents by Inventor Sergio Lociuro

Sergio Lociuro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of antibiotic GE2270 factors C.sub.2a, D.sub.2 and E
    Patent number: 6008225
    Abstract: Mono- or di-substituted derivatives of GE2270 factors C.sub.2a, D.sub.2 and E of general formula (I), wherein W represents a moiety of formula (a), (b) or (c), R.sup.1 and R.sup.2 representing a variety of substituents, X.sup.1 is methyl, X.sup.2 is a --CH.sub.2 --W.sup.1 moiety and X.sup.3 is methylamino or amino, or X.sup.1 is a --CH.sub.2 --W.sup.1 moiety, X.sup.2 is methoxymethylene and X.sup.3 is methylamino, with the proviso that when X.sup.3 is amino, then W must be 2-(aminocarbonyl)-pyrrolidinyl; with the further proviso that when W is 2-(aminocarbonyl)-pyrrolidinyl, then W.sup.1 cannot be hydroxy; and the pharmaceutically acceptable salts thereof. The mono- or di-substituted derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: December 28, 1999
    Assignee: BioSearch Italia, S.p.A.
    Inventors: Sergio Lociuro, Paolo Tavecchia, Romeo Ciabatti, Ermenegildo Restelli
  • Basic oxazoline-amide derivatives of GE2270 and GE2270-like antibiotics
    Patent number: 5891869
    Abstract: The present invention refers to basic oxazoline-amide derivatives of GE 2270 and GE 2270-like antibiotics of general formula (I), wherein the group GE represents the antibiotic core molecule. The amide derivatives of antibiotic GE 2270 of formula (I) are antimicrobial agents mainly active against gram positive bacteria.
    Type: Grant
    Filed: July 31, 1997
    Date of Patent: April 6, 1999
    Assignee: Biosearch Italia, S.p.A.
    Inventors: Sergio Lociuro, Pierfausto Seneci, Romeo Ciabatti
  • 36-derivatives of rifamycins and their use as antimicrobial agents
    Patent number: 5786350
    Abstract: Rifamycin antibiotic derivatives of formulae (I) and (Ia) bearing at the position 36 a substituent selected from (C.sub.1 -C.sub.8)alkyl, halo, hydroxy, (C.sub.1 -C.sub.4)acyloxy, (C.sub.1-C.sub.4)alkoxy, (C.sub.1 -C.sub.4)alkylthio, (C.sub.1 -C.sub.4)alkylamino, di(C.sub.1-C.sub.4)alkylamino and substituted 4-oxo-3-pyridinyl carbonyloxy of formula (1) obtained by reacting rifamycin with suitably substituted malonic acid. The compounds of the invention are antimicrobial agents mainly active against gram positive bacteria and fastidious gram negative bacteria showing the considerable antimicrobial activity against the rifamypicin resistant microbial strains.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: July 28, 1998
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Emilio Occelli, Sergio Lociuro, Romeo Ciabatti, Maurizio Denaro
  • Amides of antibiotic GE 2270 factors
    Patent number: 5599791
    Abstract: The present invention is directed to novel amide derivatives of antibiotic GE 2270 compounds and a process for preparing them. Said amide derivatives are antimicrobial agents active against gram positive bacteria as well as gram negative bacteria.
    Type: Grant
    Filed: July 1, 1993
    Date of Patent: February 4, 1997
    Assignee: Gruppo Lepetit SPA
    Inventors: Paolo Tavecchia, Sergio Lociuro, Romeo Ciabatti, Enrico Selva