Patents by Inventor Sergio Madrigal-Carballo

Sergio Madrigal-Carballo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210230777
    Abstract: Composite nanofibers comprising polymers and tannins, methods of making same, and methods of use. The nanofibers include a polymer, such as a synthetic polymer, and a tannin. The tannin can include condensed tannins (proanthocyanidins) and/or hydrolyzable tannins. The nanofibers exhibit a number of structural and functional characteristics, such as enhanced swelling in aqueous liquid, enhanced antibacterial activity, enhanced bacterial adsorption, enhanced fibroblast adhesion, enhanced fibroblast proliferation, and enhanced surface coating of silver nanoparticles, among others. The nanofibers can be made by electrospinning a solvent mixture comprising the synthetic polymer and the tannin in a solvent. The nanofibers can be used in methods of isolating cells, methods of filtration, and methods of detecting cells, among others.
    Type: Application
    Filed: June 11, 2020
    Publication date: July 29, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Jess Dreher Reed, Christian Gerald KRUEGER, Emilia ALFARO-VIQUEZ, Sergio MADRIGAL-CARBALLO, Hilary Urena SABORIO, Sundaram GUNASEKARAN
  • Patent number: 10912822
    Abstract: Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT) wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: February 9, 2021
    Assignee: Marine Essence Biosciences Corporation of USA
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Publication number: 20200354431
    Abstract: The present disclosure relates generally to methods for extracting or purifying collagen type I from marine animals, and uses of the purified collagen type I. Disclosed herein are the methods for the purification of highly pure mutable collagenous tissue from echinoderms. The current disclosure also relates to pharmaceutical, cosmetic and nutritional applications of the mutable collagenous tissue purified using the methods disclosed herein, and to compositions, kits and articles of manufacture made from the mutable collagenous tissue purified using the methods disclosed herein.
    Type: Application
    Filed: May 7, 2019
    Publication date: November 12, 2020
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Patent number: 10758594
    Abstract: Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT) wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: September 1, 2020
    Assignee: Marine Essence Biosciences Corporation of USA
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Publication number: 20200199185
    Abstract: Methods of purifying mucin, purified mucin, and products comprising the purified mucin. The methods include combining a mucin-containing substance with water and one or more purification agents to form a purification mixture, incubating the purification mixture for a time sufficient to form a mucin precipitate in a liquid phase, and separating the mucin precipitate from the liquid phase. The purification agents include one or more of a surfactant, a chelating agent, and a protic solvent. The mucin purified from the methods can be used alone or in combination with a biopolymer such as a tannin and chitosan and can be used to generate materials in the form of a gel, a foam, a film, or a powder.
    Type: Application
    Filed: December 20, 2019
    Publication date: June 25, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Jess Dreher Reed, Sergio Madrigal-Carballo, Michael Allen Polewski, Christian Gerald Krueger, Emilia Alfaro-Viquez
  • Publication number: 20190388517
    Abstract: Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT) wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
    Type: Application
    Filed: September 6, 2018
    Publication date: December 26, 2019
    Applicant: Marine Essence Biosciences Corporation of USA
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Publication number: 20190388586
    Abstract: Devices for guided tissue regeneration (GTR) include a matrix of chitosan and mutable collagenous tissue (MCT) wherein the chitosan is electrostatically bonded to the MCT to form MCT-chitosan composite material. The MCT can be isolated from invertebrate marine organisms, such as sponges, jellyfish, mollusks and echinoderms. The MCT-chitosan composite material can be formulated as a biofilm, a 3D-sponge, a hydrogel, or as an electrospun nanofiber, or the MCT-chitosan composite material can coat a biomaterial surface. The devices can include wound dressings and tissue sponges, including 3D sponges. Applications include tissue engineering and wound healing, as well as burns and other related guided tissue regeneration applications. MCT and MCT-chitosan composite material, contained in a pharmaceutically acceptable topical carrier, also has cosmeceutical applications, for treating scars, as well as skin discoloration and various pigmentation issues, including melasma/chloasma.
    Type: Application
    Filed: September 6, 2018
    Publication date: December 26, 2019
    Applicant: Marine Essence Biosciences Corporation of USA
    Inventors: Danny Qiu, Sergio Madrigal Carballo
  • Patent number: 10104888
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: October 23, 2018
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
  • Publication number: 20170142967
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Application
    Filed: December 15, 2016
    Publication date: May 25, 2017
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
  • Patent number: 9545423
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: January 17, 2017
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
  • Publication number: 20140134238
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Application
    Filed: December 23, 2013
    Publication date: May 15, 2014
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
  • Patent number: 8642088
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: February 4, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo
  • Publication number: 20110059162
    Abstract: The invention provides a composition comprising a matrix of chitosan and a tannin wherein the chitosan is electrostatically bonded to the tannin to form a chitosan-tannin composite material. The chitosan can be partially or fully deacetylated, and the tannin can be a monomeric or an oligomeric proanthocyanidin or a hydrolysable tannin. The chitosan-tannin composite material can be a nanoparticle, a hydrogel film, a bio-foam, or a biogel, or the chitosan-tannin composite material can coat a liposome. The composite materials can be used for drug delivery, for antibacterial and/or antifungal applications, for tissue engineering applications, for wound healing applications, or they can be used as adjuvants for vaccination, including oral vaccinations. The invention also provides methods of preparing the composite materials and their various forms.
    Type: Application
    Filed: September 3, 2010
    Publication date: March 10, 2011
    Inventors: Jess Dreher Reed, Christian Gerald Krueger, Sergio Madrigal-Carballo