Patents by Inventor Sergio Paoletti
Sergio Paoletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9932416Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.Type: GrantFiled: February 26, 2015Date of Patent: April 3, 2018Assignee: Universita' Degli Studi Di TriesteInventors: Sergio Paoletti, Roberto Di Lenarda, Lorenzo Breschi, Milena Cadenaro, Marina Diolosa', Gianluca Turco, Ivan Donati
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Publication number: 20160362503Abstract: The present invention concerns the preparation of chemically modified derivatives of chitosan with acrylic groups and their use in the field of enamel-dentin adhesives. Chitosan derivatives have physical-chemical features (hydrophilicity, presence of electrical charges on the chain) which allow them to interact with the organic part of the demineralized tooth. At the same time, the acrylic groups incorporated in the polymer chain allow the formation of a covalent bond with the restorative material used in the dental field that is typically composed of acrylic resins. By combining the adhesion to the tooth surface and the bond with the restorative material, the chemically modified chitosan described herein is able to increase the lifespan of the dental restoration and can thus find use in the field of adhesives, in particular enamel-dentin adhesives.Type: ApplicationFiled: February 26, 2015Publication date: December 15, 2016Inventors: Sergio Paoletti, Roberto Di Lenarda, Lorenzo Breschi, Milena Cadenaro, Marina Diolosa, Gianluca Turco, Ivan Donati
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Patent number: 8951991Abstract: Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behavior with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behavior renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.Type: GrantFiled: May 21, 2007Date of Patent: February 10, 2015Assignee: Universita Degli Studi di TriesteInventors: Sergio Paoletti, Ivan Donati, Eleonora Marsich
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Patent number: 8329635Abstract: The present invention relates to new compounds useful for the stimulation of the production of antibodies. Said compounds comprises a saccharidic tumor antigen and a polymeric scaffold. The present invention also encompasses conjugated compounds useful in ELISA assay for the selection of antibodies against saccharidic antigens.Type: GrantFiled: June 19, 2007Date of Patent: December 11, 2012Assignee: Bracco Imaging S.p.A.Inventors: Fulvio Uggeri, Cristiana Campa, Sergio Paoletti, Anna Coslovi, Alfonso Colombatti, Carla Danussi
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Publication number: 20110129536Abstract: The present invention provides nanocomposite systems made of metallic nanoparticles stabilized with branched cationic polysaccharides, in particular alditolic or aldonic mono- and oligo-saccharidic derivatives of chitosan, and their preparation obtainable with aqueous solutions of these polysaccharides in the presence or absence of reducing agents. The peculiar chemical and physical-chemical features of these polysaccharides allow to form metallic nanoparticles homogeneously dispersed in the polysaccharidic matrix and an effective stabilization thereof. The properties associated with the nanometric dimensions and the presence of biological signals on polymeric chains may be exploited in applications with antimicrobial activities and of molecular biosensors.Type: ApplicationFiled: July 22, 2009Publication date: June 2, 2011Applicant: Universita Degli Studi di TriesteInventors: Ivan Donati, Eleonora Marsich, Andrea Travan, Sergio Paoletti
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Publication number: 20110123589Abstract: In the present invention nanocomposite materials in form of three-dimensional structure formed by a polymeric matrix consisting of a polysaccharidic composition of neutral or anionic polysaccharides and a branched cationic polysaccharides, in which metallic nanoparticles are uniformly dispersed and stabilized, are described. Using appropriate techniques of gelification or by means of an appropriate dehydration, the nanocomposite materials are three-dimensional matrices having different shapes in hydrated form as hydrogels, or in non-hydrated form. These nanocomposite materials have a broad-spectrum of strong bactericidal activity, but do not show any cytotoxicity.Type: ApplicationFiled: July 22, 2009Publication date: May 26, 2011Applicant: Universita Degil Studi di TriesteInventors: Ivan Donati, Eleonora Marsich, Andrea Travan, Sergio Paoletti
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Publication number: 20100166656Abstract: The present invention refers to diagnostically or radiotherapeutically useful compounds which are able to selectively bind to lectins, having formula (I) wherein R, R?, R1, R2 and R3 are as defined in the specification; the process for their preparation and the pharmaceutical compositions thereof.Type: ApplicationFiled: February 20, 2008Publication date: July 1, 2010Applicant: BRACCO IMAGING S.P.A.Inventors: Cristiana Campa, Fulvio Uggeri, Sergio Paoletti, Anna Flamigni
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Publication number: 20090202580Abstract: The present invention relates to new compounds useful for the stimulation of the production of antibodies. Said compounds comprises a saccharidic tumor antigen and a polymeric scaffold. The present invention also encompasses conjugated compounds useful in ELISA assay for the selection of antibodies against saccharidic antigens.Type: ApplicationFiled: June 19, 2007Publication date: August 13, 2009Applicant: Bracco Imaging SpAInventors: Fulvio Uggeri, Cristiana Campa, Sergio Paoletti, Anna Coslovi, Alfonso Colombatti, Carla Danussi
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Publication number: 20090202640Abstract: The present invention describes the preparation of hydrogels (or 3D matrices) obtainable from aqueous solutions of mixtures of acid polysaccharides and derivatives of basic polysaccharides, such as oligosaccharide derivatives of chitosan. Said solutions are suitably gelled with either chemical or physical gelling agents with the aim of encapsulating either cells, isolated or in multicellular associations, or pharmacologically active molecules, in solution or suspension, for use in the biomedical and pharmaceutical field.Type: ApplicationFiled: May 21, 2007Publication date: August 13, 2009Applicant: Universita Degli Studi di TriesteInventors: Sergio Paoletti, Ivan Donati, Eleonora Marsich
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Publication number: 20090197832Abstract: Described in the present application are compositions comprising mixtures of polyanionic polysaccharides and polycationic polysaccharides consisting of oligosaccharide derivatives of chitosan. In the compositions of the invention said mixtures have proven to be soluble in aqueous environments, despite ionic complexes forming between the acid polysaccharides and chitosan derivatives. Said compositions have also demonstrated significant rheological behaviour with an unexpected increase in viscosity and viscoelasticity, although the polysaccharides used have relatively low average molecular weights. The said solubility and rheological behaviour renders the compositions of the invention particularly advantageous from the biomedical application viewpoint, in particular for viscosupplementation and particularly in the field of articular pathologies and of ophthalmic surgery.Type: ApplicationFiled: May 21, 2007Publication date: August 6, 2009Applicant: UNIVERSITA' DEGLI STUDI DI TRIESTEInventors: Sergio Paoletti, Ivan Donati, Eleonora Marsich
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Patent number: 5514339Abstract: A test tube stopper (1) has the shape of a small bowl and is provided with a protruding upper circular collar (11). The stopper (1) slidably enters into and seals the neck of a test tube (3) until the collar (11) rests against the mouth of the test tube (3). A horizontal bottom wall (12) of the stopper (1) is comprised of two or more elastically yielding sectors (16) which can bend under the action of a device (43) being introduced into the test tube (3) through the bottom wall (12) for introducing or withdrawing liquid. The resilient sectors (16) return to their initial position as soon as the device (43) has been extracted from the test tube (3) through the bottom wall (12). In a preferred embodiment a stopper (2), preferably of the conventional type, sealingly closes a cavity (14) of the stopper (1) to ensure sealing a vacuum previously provided in the test tube (3). The stopper (2) may then be removed when it is necessary to withdraw blood from the test tube (3).Type: GrantFiled: March 28, 1990Date of Patent: May 7, 1996Inventors: Francesco Leopardi, Sergio Paoletti
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Patent number: 5433716Abstract: A safety closing device for containers of biological liquids and, particularly, for test tubes used for the drawing, transport and/or analysis of blood. The safety closing device includes an undercap and a cap, both with central portions made of a perforable material. The central portion of the undercap is sealingly locked on the edge of the test tube and the central portion of the cap is sealingly locked on the side facing the undercap. A locking mechanism, that can only be intentionally disengaged, mechanically couples the cap to the undercap, and secures the cap/undercap assembly onto the prearranged open end of the test tube.Type: GrantFiled: April 27, 1993Date of Patent: July 18, 1995Assignee: Heisenberg Finance S.A.Inventors: Francesco Leopardi, Sergio Paoletti, Daniele P. Salome
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Patent number: 4622847Abstract: In an apparatus for measuring the rate of erythrosedimentation of the blood a bell mouthed test tube is provided, having a cylindrical part in which a calibrated and graduated sealing tube, topped with an overflow sleeve for the excess blood, slides. This overflow sleeve allows an automatic filling with blood of the calibrated tube independently from the care taken in the filling of the tapered test tube.Type: GrantFiled: October 7, 1983Date of Patent: November 18, 1986Assignee: L.P. Italiana S.p.A.Inventors: Sergio Paoletti, Francesco Leopardi