Patents by Inventor Sergio Penco

Sergio Penco has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
    Patent number: 8222231
    Abstract: Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: July 17, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities
    Patent number: 8101793
    Abstract: Are described compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: January 24, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Lucio Merlini, Sabrina Dallavalle, Sergio Penco, Giuseppe Giannini, Claudio Pisano, Loredana Vesci
  • Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
    Patent number: 8067555
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Grant
    Filed: August 8, 2007
    Date of Patent: November 29, 2011
    Assignee: Sigma-Tau Research Switzerland S.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • NOVEL DUAL TARGETING ANTITUMORAL CONJUGATES
    Publication number: 20110160147
    Abstract: The present invention relates to dual-targeting cytotoxic compounds of formula (I) and to their preparation. The described compounds are endowed with tumour specific action, incorporating three functional units: a tumour recognition moiety and a tumour selective enzymatic substrate sequence connected together by means of a spacer. These conjugates are designed to guarantee serum stability and, at the same time, the desired action inside the tumour cells as a result of enzymatic cleavability. [(L-D)nE]m-F-D-PI-SI-CT Formula (I).
    Type: Application
    Filed: September 2, 2009
    Publication date: June 30, 2011
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Alma Dal Pozzo, Emiliano Esposito, Minghong Ni, Sergio Penco, Claudio Pisano, Massimo Castorina, Loredana Vesci
  • DERIVATIVES OF PARTIALLY DESULPHATED GLYCOSAMINOGLYCANS ENDOWED WITH ANTIANGIOGENIC ACTIVITY AND DEVOID OF ANTICOAGULATING EFFECT
    Publication number: 20100298263
    Abstract: Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: August 5, 2010
    Publication date: November 25, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect
    Patent number: 7790700
    Abstract: Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives exhibit antiangiogenic activity and are devoid of anticoagulant activity.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: September 7, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
    Patent number: 7781416
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: August 24, 2010
    Assignee: Sigma-Tau Research Switzerland S.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
    Patent number: 7728039
    Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumor, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumors.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: June 1, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Franco Zunino, Sabrina Dallavalle, Lucio Merlini, Sergio Penco
  • Camptothecins conjugated in position 7 to cyclic peptides as cytostatic agents
    Patent number: 7705012
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: April 27, 2010
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Instituto Nazionale per lo Studio e la Cura Dei Tumori
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Ornella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • 7-Polyaminoalkyl(oxy)iminomethylcamptothecins bearing protective groups
    Patent number: 7612081
    Abstract: Compounds are disclosed with the general formula in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumors and viral and parasite infections.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: November 3, 2009
    Assignees: Istituto Nazionale per lo Studio e la Cura dei Tumori, Sigma Tau Industrie Farvaceutiche Riunite S.p.A.
    Inventors: Giuseppe Giannini, Claudio Pisano, Loredana Vesci, Maria Ornella Tinti, Lucio Merlini, Sergio Penco, Franco Zunino
  • 7-t-butoxyiminomethylcamptothecin conjugated in position 20 with integrin antagonists
    Patent number: 7589099
    Abstract: Compounds of Formula (I) are described: in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Grant
    Filed: April 28, 2005
    Date of Patent: September 15, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Ming Hong, Sabrina Dallavalle, Lucio Merlini, Maria Ornella Tinti, Franco Zunino
  • Biphenyl and Naphthyl-Phenyl Hydroxamic Acid Derivatives
    Publication number: 20080319082
    Abstract: Biphenyl and phenyl-naphthyl compounds bearing a hydroxamic group, which are endowed with antitumour, and anti-angiogenic activity These compounds are therefore particularly useful for the treatment of drug-resistant tumours.
    Type: Application
    Filed: May 31, 2006
    Publication date: December 25, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Franco Zunino, Sabrina Dallavalle, Lucio Merlini, Sergio Penco
  • Retinoid derivatives with antiangiogenic, antitumoral and proapoptotic activities
    Patent number: 7449495
    Abstract: Described and claimed are compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: November 11, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Sabrina Dallavalle, Lucio Merlini, Claudio Pisano, Loredana Vesci, Giuseppe Giannini, Sergio Penco
  • Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
    Publication number: 20080139503
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: October 31, 2007
    Publication date: June 12, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Maria Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • 7-imino derivatives of camptothecin having antitumor activity
    Patent number: 7351714
    Abstract: Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: April 1, 2008
    Assignees: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Istituto Nazionale per Lo Studio E La Cura Dei Tumori
    Inventors: Sabrina Dallavalle, Sergio Penco, Claudio Pisano, Franco Zunino
  • Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
    Publication number: 20080051567
    Abstract: Partially desulphated glycosaminoglycan derivatives are described, particularly heparin, and more particularly a compound of formula (I) where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan derivatives have antiangiogenic and heparanase-inhibiting activity and are devoid of anticoagulant activity.
    Type: Application
    Filed: August 8, 2007
    Publication date: February 28, 2008
    Applicant: Sigma-Tau Industrie FarmaceuticheRiunite S.p.A.
    Inventors: Benito Casu, Giangiacomo Torri, Anna Naggi, Giuseppe Giannini, Claudio Pisano, Sergio Penco
  • Camptothecins Conjugated in Position 7 to Cyclic Peptides as Cytostatic Agents
    Publication number: 20080033003
    Abstract: Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Application
    Filed: May 4, 2005
    Publication date: February 7, 2008
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Omella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • Retinoid Derivatives With Antiangiogenic, Antitumoral And Proapoptotic Activities
    Publication number: 20080021088
    Abstract: Described and claimed are compounds of Formula (I) in which R, R?, R?, A, and D have the meanings described in the text, as useful agents in the cure of pathologies characterized by altered angiogenesis and as antitumorals.
    Type: Application
    Filed: June 20, 2007
    Publication date: January 24, 2008
    Inventors: Sabrina Dallavalle, Lucio Merlini, Claudio Pisano, Loredana Vesci, Giuseppe Giannini, Sergio Penco
  • Camptothecin Derivatives Conjugated in Position 20 with Integrin Antagonists
    Publication number: 20070232639
    Abstract: Compounds or formula (I) are described, in which the R and R1 groups are as defined here below and include the condensation of the camptothecin molecule in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Application
    Filed: May 4, 2005
    Publication date: October 4, 2007
    Inventors: Claudio Pisano, Giuseppe Giannini, Maria Ornella Tinti, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini, Franco Zunino
  • 7-T-Butoxyiminomethylcamptothecin Conjugated in Position 20 With Integrin Antagonists
    Publication number: 20070225311
    Abstract: Compounds of Formula (I) are described: in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors ?v?3 and ?v?5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 27, 2007
    Inventors: Claudio Pisano, Giuseppe Giannini, Loredana Vesci, Domenico Alloatti, Sergio Penco, Alma Dal Pozzo, Ni Minghong, Sabrina Dallavalle, Lucio Merlini