Patents by Inventor Sergiy Krasutsky

Sergiy Krasutsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of N-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
    Patent number: 11629150
    Abstract: This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
    Type: Grant
    Filed: December 14, 2020
    Date of Patent: April 18, 2023
    Assignee: G1 Therapeutics, Inc.
    Inventors: Alexander Smith, Hannah S. White, Francis Xavier Tavares, Sergiy Krasutsky, Jian-Xie Chen, Roberta L. Dorrow, Hua Zhong
  • PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF
    Publication number: 20220162168
    Abstract: A method of preparing 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid tosylate addition salts is provided, which involves direct conversion of esters of Formula V as described herein to acids of Formula VIII as described herein. Tosylate addition salts of Formula IX as described herein are then prepared from the acids of Formula VIII.
    Type: Application
    Filed: February 11, 2022
    Publication date: May 26, 2022
    Inventors: Ananya Sengupta, Sergiy KRASUTSKY, Scott TWEEDIE, Gurusankar RAMAMOORTHY
  • INHIBITORS OF RORgamma
    Publication number: 20210230158
    Abstract: The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.
    Type: Application
    Filed: January 8, 2021
    Publication date: July 29, 2021
    Inventors: Robert J. Duguid, John A. Grosso, Sergiy Krasutsky
  • SYNTHESIS OF N-(HETEROARYL)-PYRROLO[3,2-D]PYRIMIDIN-2-AMINES
    Publication number: 20210122755
    Abstract: This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
    Type: Application
    Filed: December 14, 2020
    Publication date: April 29, 2021
    Applicant: G1 Therapeutics, Inc.
    Inventors: Alexander Smith, Hannah S. White, Francis Xavier Tavares, Sergiy Krasutsky, Jian-Xie Chen, Roberta L. Dorrow, Hua Zhong
  • Inhibitors of ROR?
    Patent number: 10913739
    Abstract: The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.
    Type: Grant
    Filed: July 24, 2018
    Date of Patent: February 9, 2021
    Assignee: Vitae Pharmaceuticals, LLC (121374)
    Inventors: Robert J. Duguid, John A. Grosso, Sergiy Krasutsky
  • Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom
    Patent number: 10875831
    Abstract: A method for preparing an alkyl 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylate ester is described herein. The method comprises cyclizing a compound of Formula III with Eaton's reagent in heated continuous flow reactor to form a compound of Formula IV wherein in Formula III and Formula IV, each X independently is a halogen atom; and each R independently is C1 to C4 alkyl. Optionally, a cosolvent such as dichloromethane can be included with the Eaton's reagent. A method of preparing a diphenylureido-dihalokynurenic acid alkyl ester of Formula VI from the compound of Formula IV also is described.
    Type: Grant
    Filed: August 12, 2019
    Date of Patent: December 29, 2020
    Assignee: Lohocla Research Corporation
    Inventors: Sergiy Krasutsky, Scott Tweedie, Gurusankar Ramamoorthy
  • Synthesis of n-(heteroaryl)-pyrrolo[3,2-d]pyrimidin-2-amines
    Patent number: 10865210
    Abstract: This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 15, 2020
    Assignee: G1 Therapeutics, Inc.
    Inventors: Alexander Smith, Hannah S. White, Francis Xavier Tavares, Sergiy Krasutsky, Jian-Xie Chen, Roberta L. Dorrow, Hua Zhong
  • INHIBITORS OF RORgamma
    Publication number: 20200148677
    Abstract: The present disclosure relates to processes for the production of salts and crystalline forms of a compound having the formula.
    Type: Application
    Filed: July 24, 2018
    Publication date: May 14, 2020
    Inventors: Robert J. Duguid, John A. Grosso, Sergiy Krasutsky
  • SYNTHESIS OF N-(HETEROARYL)-PYRROLO[3,2-D]PYRIMIDIN-2-AMINES
    Publication number: 20190135820
    Abstract: This invention is in the area of synthesizing pyrimidine-based compounds useful in the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.
    Type: Application
    Filed: December 21, 2018
    Publication date: May 9, 2019
    Applicant: G1 Therapeutics, Inc.
    Inventors: Alexander Smith, Hannah S. White, francis Xavier Tavares, Sergiy Krasutsky, Jian-Xie Chen, Roberta L. Dorrow, Hua Zhong