Patents by Inventor Sergiy Levin

Sergiy Levin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Acid-labile surfactants
    Patent number: 11939311
    Abstract: Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: March 26, 2024
    Assignee: Promega Corporation
    Inventors: Joel Walker, Sergei Saveliev, Zhiyang Zeng, Robert Kargbo, Hui Wang, Sergiy Levin, Valerie Ressler, Jun Zhang, Ce Shi, Harry Tetsuo Uyeda, Jean Osterman, Min Zhou, Prabin Rai, Wenhui Zhou
  • Photoaffinity probes
    Patent number: 11913944
    Abstract: Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.
    Type: Grant
    Filed: March 20, 2020
    Date of Patent: February 27, 2024
    Assignee: Promega Corporation
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Robin Hurst, Thomas Kirkland, Keith Wood
  • Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
    Patent number: 11667648
    Abstract: Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: June 6, 2023
    Assignee: Promega Corporation
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith V. Wood
  • SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
    Publication number: 20210340593
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Application
    Filed: July 13, 2021
    Publication date: November 4, 2021
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Sergiy Levin, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • ACID-LABILE SURFACTANTS
    Publication number: 20210040058
    Abstract: Provided herein are surfactant compounds that can be used to aid in preparation of protein samples for analysis, for example by mass spectrometry.
    Type: Application
    Filed: August 6, 2020
    Publication date: February 11, 2021
    Inventors: Joel Walker, Sergei Saveliev, Zhiyang Zeng, Robert Kargbo, Hui Wang, Sergiy Levin, Valerie Ressler, Jun Zhang, Ce Shi, Harry Tetsuo Uyeda, Jean Osterman, Min Zhou, Prabin Rai, Wenhui Zhou
  • Palladium catalysts with improved performance in biological environments
    Patent number: 10882035
    Abstract: Provided herein are palladium (Pd) catalysts with improved performance in biological environments. In particular, formulations, methods of preparations, and storage conditions are provided that provide improved performance of Pd catalysts under protein-rich conditions.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: January 5, 2021
    Assignee: Promega Corporation
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith Wood
  • PHOTOAFFINITY PROBES
    Publication number: 20200340982
    Abstract: Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.
    Type: Application
    Filed: March 20, 2020
    Publication date: October 29, 2020
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Robin Hurst, Thomas Kirkland, Keith Wood
  • CELL-PERMEABLE, CELL-COMPATIBLE, AND CLEAVABLE LINKERS FOR COVALENT TETHERING OF FUNCTIONAL ELEMENTS
    Publication number: 20200199140
    Abstract: Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 25, 2020
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith V. Wood
  • BROAD SPECTRUM GPCR BINDING AGENTS
    Publication number: 20200200765
    Abstract: Provided herein are broad-spectrum G-Protein coupled receptor (GPCR) binding agents, detectable/isolatable compounds comprising such binding agents (e.g., broad-spectrum GPCR binding agents linked to a functional element and/or solid surface), and methods of use thereof for the detection/isolation of GPCRs.
    Type: Application
    Filed: December 4, 2019
    Publication date: June 25, 2020
    Inventors: Sergiy Levin, Michelle Boursier, Rachel Friedman Ohana, Thomas Kirkland, Keith Wood
  • Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
    Patent number: 10618907
    Abstract: Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 14, 2020
    Assignee: PROMEGA CORPORATION
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith V. Wood
  • Methods for synthesizing rhodamine dyes
    Patent number: 10093806
    Abstract: Described herein are methods for the regioselective synthesis of substituted rhodamine dyes.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: October 9, 2018
    Assignee: PROMEGA CORPORATION
    Inventors: Stephen J. Dwight, Sergiy Levin
  • PALLADIUM CATALYSTS WITH IMPROVED PERFORMANCE IN BIOLOGICAL ENVIRONMENTS
    Publication number: 20180029028
    Abstract: Provided herein are palladium (Pd) catalysts with improved performance in biological environments. In particular, formulations, methods of preparations, and storage conditions are provided that provide improved performance of Pd catalysts under protein-rich conditions.
    Type: Application
    Filed: May 10, 2017
    Publication date: February 1, 2018
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith Wood
  • METHODS FOR SYNTHESIZING RHODAMINE DYES
    Publication number: 20170096560
    Abstract: Described herein are methods for the regioselective synthesis of substituted rhodamine dyes.
    Type: Application
    Filed: September 30, 2016
    Publication date: April 6, 2017
    Inventors: Stephen J. Dwight, Sergiy Levin
  • Cysteine hydrazide nicotinamide for glycomics and glycoproteomics uses
    Patent number: 9541558
    Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: January 10, 2017
    Assignee: California Institute of Technology
    Inventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman
  • CELL-PERMEABLE, CELL-COMPATIBLE, AND CLEAVABLE LINKERS FOR COVALENT TETHERING OF FUNCTIONAL ELEMENTS
    Publication number: 20160355523
    Abstract: Provided herein are cell-permeable, cell-compatible, and chemoselectively-cleavable linkers for tethering (e.g., covalently) functional elements (e.g., a cellular interaction element and a capture element), and methods of use (e.g., intracellular capture and extracellular release of cellular targets) therewith.
    Type: Application
    Filed: June 3, 2016
    Publication date: December 8, 2016
    Inventors: Sergiy Levin, Rachel Friedman Ohana, Thomas Kirkland, Keith V. Wood
  • SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
    Publication number: 20140322794
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 30, 2014
    Applicant: PROMEGA CORPORATION
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Sergiy Levin, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES
    Publication number: 20140322738
    Abstract: The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 30, 2014
    Applicant: PROMEGA CORPORATION
    Inventors: Carolyn W. Hitko, Thomas Kirkland, Sergiy Levin, Poncho Meisenheimer, Rachel Friedman Ohana, Harry Tetsuo Uyeda, Ji Zhu
  • CYSTEINE HYDRAZIDE NICOTINAMIDE FOR GLYCOMICS AND GLYCOPROTEOMICS USES
    Publication number: 20140072981
    Abstract: A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also provided.
    Type: Application
    Filed: September 4, 2013
    Publication date: March 13, 2014
    Applicant: California Institute of Technology
    Inventors: William M. Clemons, Kyoung-Soon Jang, Roger Nani, Sergiy Levin, Sarah Reisman