Patents by Inventor Sergiy M. DENYSENKO

Sergiy M. DENYSENKO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoselective synthesis and process for the manufacturing of 2?-deoxynucleosides
    Patent number: 11365211
    Abstract: Methods for stereoselective synthesis and manufacturing of 2?-deoxynucleosides, such as 2?-ribonucleosides, are disclosed. In some embodiments, the 2?-deoxynucleoside is a ?-anomer of a 2?-deoxynucleoside having a 3? ? hydroxyl, 4? ? hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4?-thio-2?-deoxycytidine (T-dCyd) and 5-aza-4?-thio-2?-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 21, 2022
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Lianhao Zhang, Baburao Vishnuvajjala, Joel Morris, Robert Bahde, Sergiy M. Denysenko, Omar Diego Lopez, Donn Gregory Wishka
  • STEREOSELECTIVE SYNTHESIS AND PROCESS FOR THE MANUFACTURING OF 2'-DEOXYNUCLEOSIDES
    Publication number: 20200361977
    Abstract: Methods for stereoselective synthesis and manufacturing of 2?-deoxynucleosides, such as 2?-ribonucleosides, are disclosed. In some embodiments, the 2?-deoxynucleoside is a ?-anomer of a 2?-deoxynucleoside having a 3? ? hydroxyl, 4? ? hydroxymethyl configuration. Nonlimiting examples of compounds prepared by the disclosed methods include 4?-thio-2?-deoxycytidine (T-dCyd) and 5-aza-4?-thio-2?-deoxycytidine (5-aza-T-dCyd; aza-T-dCyd; aza-T-dC).
    Type: Application
    Filed: January 30, 2019
    Publication date: November 19, 2020
    Applicants: The USA, as represented by the Secretary, Department of Health and Human Services, Alchem Laboratories Corporation
    Inventors: Lianhao Zhang, Baburao Vishnuvajjala, Joel Morris, Robert Bahde, Sergiy M. Denysenko, Omar Diego Lopez, Donn Gregory Wishka
  • Process for preparing Z-endoxifen of high purity
    Patent number: 10464881
    Abstract: Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) at least 1.3 times greater than the ratio in the input crystalline solid (1) and (2); (ii) recrystallizing a solid produced by concentrating the first mother liquor, or by removal of the first solvent from the first mother liquor, from a second solvent to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent one to five additional times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) greater than 20:1.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: November 5, 2019
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, ALCHEM LABORATORIES CORPORATION
    Inventors: Paul S. Liu, Sergiy M. Denysenko, Guangfei Huang
  • PROCESS FOR PREPARING Z-ENDOXIFEN OF HIGH PURITY
    Publication number: 20180305295
    Abstract: Disclosed is a process for preparing (Z)-endoxifen, comprising (i) recrystallizing an input crystalline solid comprising a mixture of (Z)-endoxifen (1) and (E)-endoxifen (2) from a first solvent to provide a first crystalline solid and a first mother liquor, wherein the first mother liquor has a ratio of (1) to (2) at least 1.3 times greater than the ratio in the input crystalline solid (1) and (2); (ii) recrystallizing a solid produced by concentrating the first mother liquor, or by removal of the first solvent from the first mother liquor, from a second solvent to give a second crystalline solid and a second mother liquor; (iii) optionally recrystallizing the second crystalline solid from the second solvent one to five additional times to give a third crystalline solid; wherein the third crystalline solid has a ratio of (Z)-endoxifen (1) to (E)-endoxifen (2) greater than 20:1.
    Type: Application
    Filed: October 24, 2016
    Publication date: October 25, 2018
    Inventors: Paul S. LIU, Sergiy M. DENYSENKO, Guangfei HUANG