Patents by Inventor Serguei Fine

Serguei Fine has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080319191
    Abstract: The present invention provides a novel crystalline form of linezolid referred to herein as Form IV as well as methods for the preparation and use of Form IV. The present invention provides pharmaceutical compositions that comprise therapeutically effective amounts of Form IV that can be used to treat patients suffering from gram-positive bacterial infections. Various processes for making crystalline linezolid Form IV are disclosed.
    Type: Application
    Filed: August 22, 2008
    Publication date: December 25, 2008
    Inventors: Judith Aronhime, Tamas Koltai, Viviana Braude, Serguei Fine, Tamar Niddam
  • Publication number: 20080045707
    Abstract: The present invention provides improved methods of converting R—N-(4-morpholiyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl azide (III) to the intermediate S—N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine (II) that involve the production of fewer by-products than previous methods. The amine (II) may then be converted into linezolid (I) of high chemical purity with respect to the inactive R-enantiomer and bis-linezolid (IV), and is in high yield, without the need for tedious, complicated purification steps, such as chromatography.
    Type: Application
    Filed: October 23, 2007
    Publication date: February 21, 2008
    Inventors: Serguei Fine, Tamar Nidam, Viviana Braude
  • Patent number: 7291614
    Abstract: The present invention provides improved methods of converting R—N-(4-morpholiyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl azide (III) to the intermediate S—N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine (II) that involve the production of fewer by-products than previous methods. The amine (II) may then be converted into linezolid (I) of high chemical purity with respect to the inactive R-enantiomer and bis-linezolid (IV), and is in high yield, without the need for tedious, complicated purification steps, such as chromatography.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: November 6, 2007
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Serguei Fine, Tamar Nidam, Viviana Braude
  • Publication number: 20070117987
    Abstract: Provided is a process for preparing valsartan and precursors thereof.
    Type: Application
    Filed: July 5, 2006
    Publication date: May 24, 2007
    Inventors: Viviana Braude, Serguei Fine, Slavik Yurkovsky, Evgeny Tsiperman
  • Publication number: 20070021417
    Abstract: The present invention provides improved methods of converting R-N-(4-morpholiyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl azide (III) to the intermediate S-N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine (II) that involve the production of fewer by-products than previous methods. The amine (II) may then be converted into linezolid (I) of high chemical purity with respect to the inactive R-enantiomer and bis-linezolid (IV), and is in high yield, without the need for tedious, complicated purification steps, such as chromatography.
    Type: Application
    Filed: February 23, 2006
    Publication date: January 25, 2007
    Inventors: Serguei Fine, Tamar Nidam, Viviana Braude
  • Publication number: 20060258655
    Abstract: The present invention relates to novel crystalline forms of the linezolid intermediate S—N-(4-morpholinyl-3-fluorophenyl)-2-oxo-5-oxazolidinyl-methyl amine referred to herein as Form A, Form B, and Form C.
    Type: Application
    Filed: February 24, 2006
    Publication date: November 16, 2006
    Inventors: Tamas Koltai, Tamar Nidam, Viviana Braude, Serguei Fine
  • Publication number: 20060142283
    Abstract: The present invention provides a novel crystalline form of linezolid referred to herein as Form IV as well as methods for the preparation and use of Form IV. The present invention provides pharmaceutical compositions that comprise therapeutically effective amounts of Form IV that can be used to treat patients suffering from gram-positive bacterial infections. Various processes for making crystalline linezolid Form IV are disclosed.
    Type: Application
    Filed: June 29, 2005
    Publication date: June 29, 2006
    Inventors: Judith Aronhime, Tamas Koltai, Viviana Braude, Serguei Fine, Tamar Niddam
  • Publication number: 20060111350
    Abstract: Novel crystalline forms of Linezolid, designated as Form TIII, Form V, Form VI, Form IX, Form X, Form XII, Form XIV, Form XVII, and Form XVIII, are disclosed. The novel crystalline forms are characterized by powder X-ray diffraction, FTIR and FTRaman spectroscopy, and differential scanning calorimetry. Methods of preparing the novel crystalline forms, pharmaceutical compositions comprising the novel crystalline forms, and methods of using the novel crystalline forms to treat gram positive bacterial infections are also described. Amorphous Linezolid is also disclosed.
    Type: Application
    Filed: June 29, 2005
    Publication date: May 25, 2006
    Inventors: Judith Aronhime, Tamas Koltai, Viviana Braude, Serguei Fine, Tamar Niddam
  • Publication number: 20060106086
    Abstract: Provided are processes for preparation of tegaserod and the maleate salt thereof.
    Type: Application
    Filed: April 26, 2005
    Publication date: May 18, 2006
    Inventors: Santiago Ini, Anita Liberman, Serguei Fine