Patents by Inventor Serguei V. Kotenko

Serguei V. Kotenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cells expressing IL-10 receptor and the CRFB4 gene product, an IL-10 receptor accessory protein
    Patent number: 5843697
    Abstract: The present invention relates to the identification of intracellular signal transduction function for a putative cytokine receptor subunit. In particular, the invention relates to the identification of the signal transduction protein for the interleukin (IL)-10 receptor. Accordingly, the present invention relates to preparing recombinant cells that express the IL-10 receptor and the newly identified IL-10 signal transduction protein, e.g., for use in screening libraries of compounds for IL-10 agonists and antagonists; to restoring IL-10 function to cells in vivo, e.g., via gene therapy; and in addition to chimeric proteins comprising this signal transduction protein to agonize IL-10 activity. In specific examples, cells transfected with both the first chain of the IL-10R and the presently identified second chain, termed herein CRFB4, were able to transduce a signal in response to contact with IL-10.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: December 1, 1998
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Sidney Pestka, Serguei V. Kotenko