Patents by Inventor Serguei V. Kovalenko

Serguei V. Kovalenko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Site-specific cleavage of nucleic acids by photoreactive conjugates
    Patent number: 8242307
    Abstract: A process of forming a double strand cleavage in DNA includes providing a reaction mixture containing double stranded DNA having a break in a first strand defining a target site in a second strand. The method continues by adding to the reaction mixture a photoreactive lysine conjugate selected from a lysine-enediyne conjugate, a lysine-acetylene conjugate or a combination thereof, for a time sufficient for the lysine conjugate to bind to the DNA adjacent the target site. The reaction mixture is then irradiated with electromagnetic radiation sufficient to photoactivate the lysine conjugate to cleave the second strand adjacent the target site.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: August 14, 2012
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Igor V. Alabugin, Boris Breiner, Joerg C. Schlatterer, Serguei V. Kovalenko, Nancy L. Greenbaum
  • Preparation of Methyl Fluoroalkyl Ethers
    Publication number: 20100312019
    Abstract: Methyl fluoroalkyl ether can be produced by the reaction of a fluoroalkyl alcohol with chloromethane. The process involves reacting an alkoxide of a fluoroalkyl alcohol with chloromethane.
    Type: Application
    Filed: June 8, 2009
    Publication date: December 9, 2010
    Inventors: Serguei V. Kovalenko, Joel Swinson
  • Site-specific cleavage of nucleic acids by photoreactive conjugates
    Patent number: 7695912
    Abstract: A process of forming a double strand cleavage in DNA includes providing a reaction mixture containing double stranded DNA having a break in a first strand defining a target site in a second strand. The method continues by adding to the reaction mixture a photoreactive lysine conjugate selected from a lysine-enediyne conjugate, a lysine-acetylene conjugate or a combination thereof, for a time sufficient for the lysine conjugate to bind to the DNA adjacent the target site. The reaction mixture is then irradiated with electromagnetic radiation sufficient to photoactivate the lysine conjugate to cleave the second strand adjacent the target site.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: April 13, 2010
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Igor V. Alabugin, Boris Breiner, Joerg C. Schlatterer, Serguei V. Kovalenko, Nancy L. Greenbaum