Patents by Inventor Serhat Gumrukcu

Serhat Gumrukcu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPANDED MEMORY SUBSETS OF GAMMA DELTA T CELLS FOR IMMUNOTHERAPY
    Publication number: 20230263827
    Abstract: The present disclosure provides compositions comprising enriched gamma delta T cells and methods for generating and expanding the enriched gamma delta T cells. In certain embodiments, these enriched gamma delta T cells are used for eliciting an immune response in a subject for methods of treating and/or preventing a coronavirus infection.
    Type: Application
    Filed: September 2, 2021
    Publication date: August 24, 2023
    Inventor: SERHAT GUMRUKCU
  • COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING CORONAVIRUS INFECTIONS
    Publication number: 20220282279
    Abstract: The disclosure provides methods and compositions utilizing recombinant nucleic acid constructs encoding a chemokine, cytokine, or apoptosis inducing protein (e.g. Caspase 9 (Casp9)), or other toxins in a form which can only be transcribed in the presence of a viral polymerase. These methods can be adapted to target many viral infections and reduce or eliminate viral load, and provide a fundamentally different treatment for viral infections.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 8, 2022
    Inventor: Serhat Gumrukcu
  • Methods and compositions using recombinant dendritic cells for cancer therapy
    Patent number: 11413338
    Abstract: Disclosed herein are methods and compositions for treating cancer by eliciting an immune response by administering dendritic cells expressing heterologous proteins. In some embodiments, a dendritic cell comprises one or more heterologous nucleic acid molecules encoding for CD40L and CXCL13. In some embodiments, the dendritic cell further comprises a heterologous nucleic acid molecule encoding for CD93. In yet additional embodiments, the dendritic cells expressing heterologous proteins are activated.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: August 16, 2022
    Assignee: ENOCHIAN BIOPHARMA, INC.
    Inventor: Serhat Gumrukcu
  • COMPOSITIONS AND METHODS FOR PROVIDING CHEMOPROTECTIVE EFFECTS
    Publication number: 20220241326
    Abstract: The disclosure relates to compositions and methods for providing chemoprotective effects to target cells.
    Type: Application
    Filed: February 1, 2021
    Publication date: August 4, 2022
    Inventor: Serhat Gumrukcu
  • COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
    Publication number: 20210238232
    Abstract: The disclosure provides methods and compositions utilizing recombinant nucleic acid constructs or a replication incompetent virus-like particle encoding a chemokine, cytokine, or apoptosis inducing protein (e.g. Caspase 9 (Casp9)), or other toxins in a form which can only be transcribed in the presence of a viral polymerase. These methods can be adapted to target many viral infections and reduce or eliminate viral load, and provide a fundamentally different treatment for viral infections.
    Type: Application
    Filed: August 28, 2020
    Publication date: August 5, 2021
    Inventor: Serhat Gumrukcu
  • ALLOGENEIC T-CELL-BASED HIV VACCINE TO INDUCE CELLULAR AND HUMORAL IMMUNITY
    Publication number: 20210030795
    Abstract: Provided herein are methods for treating a patient with human immunodeficiency virus (HIV), comprising administering cellular compositions comprising recombinant allogeneic cells, such as CD4+ T cells. The present invention further relates to compositions and methods for making an allogeneic T-cell-based protective HIV vaccine that induces both cellular and humoral immunity. Related compositions and methods for modulating the immune system using such recombinant cells are also provided.
    Type: Application
    Filed: June 17, 2020
    Publication date: February 4, 2021
    Inventor: Serhat Gumrukcu
  • ACTIVATED LYMPHOCYTIC CELLS AND METHODS OF USING THE SAME TO TREAT CANCER AND INFECTIOUS CONDITIONS
    Publication number: 20210008110
    Abstract: Provided herein are methods for treating a patient with HIV, cancer, a viral infection, or a bacterial infection, comprising administering an effective amount of activated lymphocytic cellular compositions. Related compositions, kits, and methods for modulating the immune system using the activated lymphocytic cellular compositions are also provided.
    Type: Application
    Filed: June 15, 2020
    Publication date: January 14, 2021
    Inventor: Serhat Gumrukcu
  • METHODS AND COMPOSITIONS USING RECOMBINANT DENDRITIC CELLS FOR CANCER THERAPY
    Publication number: 20200016250
    Abstract: Disclosed herein are methods and compositions for treating cancer by eliciting an immune response by administering dendritic cells expressing heterologous proteins. In some embodiments, a dendritic cell comprises one or more heterologous nucleic acid molecules encoding for CD40L and CXCL13. In some embodiments, the dendritic cell further comprises a heterologous nucleic acid molecule encoding for CD93. In yet additional embodiments, the dendritic cells expressing heterologous proteins are activated.
    Type: Application
    Filed: July 15, 2019
    Publication date: January 16, 2020
    Inventor: Serhat Gumrukcu
  • METHODS AND COMPOSITIONS FOR NON-MYELOABLATIVE BONE MARROW RECONSTITUTION
    Publication number: 20190269734
    Abstract: The disclosure relates generally to methods and compositions for performing bone marrow transplants using a non-myeloablative chemotherapeutic agent and chemotherapeutic-resistant cells. Using the methods and compositions described herein, a patient's bone marrow may be reconstituted and the patient avoids adverse side effects, including myeloablation and/or an impaired immune system.
    Type: Application
    Filed: November 15, 2018
    Publication date: September 5, 2019
    Inventor: Serhat Gumrukcu