Abstract: Systems and methods for processing multiple cardiac images that depict a portion of coronary arteries within an anatomical region of interest. A respective set of lumen radius measurements is determined based on each of the multiple cardiac images and comprises multiple lumen radius measurements respectively associated with multiple locations of the portion of the coronary arteries. One or more locations of the multiple locations, at each of which at least two sets of the respective sets of lumen radius measurements all have a local or relative extremum, e.g., either a local maximum or a local minimum, are determined based on the respective sets of lumen radius measurements. Rigid-motion artifacts in the multiple cardiac images are corrected based on the one or more locations.

Abstract: A method includes receiving a plurality of images of vessels obtained from different viewing angles relative to the vessels. In each image and for a first of the vessels, a distance of different points along the first vessel relative to a reference location at the first vessel is determined, and in each image, and at each of the different points, a parameter of the first vessel for blood flow through the first vessel is determined. This provides, for each image, a data sequence indicating the parameter relative to a distance to the reference location. A sequence alignment of the data sequences obtained for the plurality of images is carried out, providing aligned data sequences. An aggregated representation of the first vessel is determined based on the aligned data sequences, and a flow parameter is determined for the first vessel from the aggregated representation.

Abstract: Techniques for processing one or more frames of an angiogram are disclosed. The processing may take place during or after an angiography exam. The one or more frames of the angiogram are acquired during the angiography exam. The one or more frames are processed to determine, based on at least one pre-defined criterion, whether the angiogram at least comprises one frame with a diagnostic value among the one or more frames. If the angiogram comprises at least one frame with the diagnostic value, based on the angiogram, a score quantifying the diagnostic value of the angiogram is determined using a trained machine-learning (ML) algorithm. Techniques for processing, e.g., ranking/sorting, multiple angiograms associated with an anatomical region of interest of a patient are also provided, by which a respective score for each of the multiple angiograms is determined using the techniques for processing one or more frames of an angiogram.

Abstract: Systems and methods for performing one or more medical imaging analysis tasks are provided. A sequence of medical images is received. One or more patches are extracted from each image of the sequence of medical images. Spatio-temporal features are extracted from the one or more extracted patches using a machine learning based encoder network. One or more medical imaging analysis tasks are performed based on the extracted spatio-temporal features. Results of the one or more medical imaging analysis tasks are output. The machine learning based encoder network is trained by receiving a sequence of training medical images. Patches of a first set of images of the sequence of training medical images are masked according to a first masking strategy. Patches of a second set of images of the sequence of training medical images are masked according to a second masking strategy.

Abstract: Angiography angles are determined. Patient information and target vessel information are obtained, wherein the patient information defines individual medical information of a patient and wherein the target vessel information defines at least one target vessel to be imaged. At least one angiography angle is determined based on the patient information and the target vessel information. Angiograms obtained using the at least one angiography angle are analyzed to determine a vessel coverage of the target vessel and based on the vessel coverage determines additional angiography angles.

Abstract: A technique is provided for tracking an object in a real-time time series of medical images. A method, performed by a downstream neural network, NN, includes receiving a real-time time series of medical images of a patient's anatomical region at an input layer of the NN. Using a spatio-temporal encoder, the real-time time series is encoded, and an encoded representation per frame is obtained. A frame corresponds to a medical image at a time instance within the real-time time series of medical images. Using a multi-head cross-attention, MCA, decoder, the encoded representation of a most recent frame is decoded. The MCA decoder correlates the most recent frame with a predefined number of preceding frames. An object is tracked. The tracking comprises determining coordinates of the object based on the decoded most recent frame.

Abstract: Systems and methods for vulnerable plaque assessment and outcome prediction in coronary artery disease. Medical imaging data is used to generate a coronary tree model of coronary centerlines of a patient. The coronary tree model includes a plurality of nodes that represent locations in the coronary tree model. Feature embedding associated with each node are determined from a plurality of features derived from the medical imaging data. The feature embeddings are input into a trained graph neural network that is configured to output an assessment at a node level, a segment level, and/or a coronary tree level for vulnerable plaque.

Abstract: At least one example embodiment provides a computer-implemented method for evaluating at least one image data set of an imaging region of a patient, wherein at least one evaluation information describing at least one medical condition in an anatomical structure of the imaging region is determined.

Abstract: Techniques for processing multiple cardiac images are disclosed. The multiple cardiac images, each of which depicts a portion of coronary arteries, i.e., the same portion of coronary arteries, within an anatomical region of interest, are obtained either during or after an angiography exam. A respective set of lumen radius measurements is determined based on each of the multiple cardiac images and comprises multiple lumen radius measurements respectively associated with multiple locations of the portion of the coronary arteries. A maximum stenosis severity profile and a minimum stenosis severity profile associated with the portion of the coronary arteries are respectively determined based on the respective sets of lumen radius measurements. A lumen radius profile associated with the portion of the coronary arteries is determined based on the maximum stenosis severity profile and the minimum stenosis severity profile.

Abstract: Techniques for adjusting or editing respective segments of a contour of a given lumen segmentation of a portion of coronary arteries are described. The respective segments of the contour are adjusted by processing multiple cardiac images. Each of the multiple cardiac images depicts a portion of coronary arteries, i.e., the same portion of coronary arteries, within an anatomical region of interest. Respective magnitudes of one or more local segmentation uncertainties are determined based on the multiple cardiac images. Each of the one or more local segmentation uncertainties is associated with a respective segment of the contour of the given lumen segmentation. The respective segments of the contour are adjusted edited or manipulated based on the respective magnitudes of the one or more local segmentation uncertainties.

Abstract: Systems and methods for performing one or more medical imaging analysis tasks are provided. A sequence of medical images is received. One or more patches are extracted from each image of the sequence of medical images. Spatio-temporal features are extracted from the one or more extracted patches using a machine learning based encoder network. One or more medical imaging analysis tasks are performed based on the extracted spatio-temporal features. Results of the one or more medical imaging analysis tasks are output. The machine learning based encoder network is trained by receiving a sequence of training medical images. Patches of a first set of images of the sequence of training medical images are masked according to a first masking strategy. Patches of a second set of images of the sequence of training medical images are masked according to a second masking strategy.

Abstract: At least one example embodiment provides a computer-implemented method for evaluating at least one image data set of an imaging region of a patient, wherein at least one evaluation information describing at least one medical condition in an anatomical structure of the imaging region is determined.

Abstract: Systems and methods for determining corresponding locations of points of interest in a plurality of input medical images are provided. A plurality of input medical images comprising a first input medical image and one or more additional input medical images is received. The first input medical image identifies a location of a point of interest. A set of features is extracted from each of the plurality of input medical images. Features between each of the sets of features are related using a machine learning based relational network. A location of the point of interest in each of the one or more additional input medical images that corresponds to the location of the point of interest in the first input medical image is identified based on the related features. The location of the point of interest in each of the one or more additional input medical images is output.

Abstract: Techniques for processing multiple cardiac images are disclosed. The processing may take place either during or after an angiography exam of a coronary artery of interest. The multiple cardiac images are obtained either during or after the angiography exam. Each of the multiple cardiac images depicts a respective segment of the coronary artery of interest. A geometric structure of the coronary artery of interest is determined based on the multiple cardiac images. A lumped parameter model of the coronary artery of interest is determined based on the geometric structure, and respective values of at least one hemodynamic index at a position of the coronary artery of interest is determined based on the lumped parameter model of the coronary artery of interest.

Abstract: At least one example embodiment provides a computer-implemented method for evaluating at least one image data set of an imaging region of a patient, wherein at least one evaluation information describing at least one medical condition in an anatomical structure of the imaging region is determined.

Abstract: Techniques for processing one or more frames of an angiogram are disclosed. The processing may take place during or after an angiography exam. The one or more frames of the angiogram are acquired during the angiography exam. The one or more frames are processed to determine, based on at least one pre-defined criterion, whether the angiogram at least comprises one frame with a diagnostic value among the one or more frames. If the angiogram comprises at least one frame with the diagnostic value, based on the angiogram, a score quantifying the diagnostic value of the angiogram is determined using a trained machine-learning (ML) algorithm. Techniques for processing, e.g., ranking/sorting, multiple angiograms associated with an anatomical region of interest of a patient are also provided, by which a respective score for each of the multiple angiograms is determined using the techniques for processing one or more frames of an angiogram.

Abstract: Angiography angles are determined. Patient information and target vessel information are obtained, wherein the patient information defines individual medical information of a patient and wherein the target vessel information defines at least one target vessel to be imaged. At least one angiography angle is determined based on the patient information and the target vessel information. Angiograms obtained using the at least one angiography angle are analyzed to determine a vessel coverage of the target vessel and based on the vessel coverage determines additional angiography angles.

Abstract: Systems and methods for determining corresponding locations of points of interest in a plurality of input medical images are provided. A plurality of input medical images comprising a first input medical image and one or more additional input medical images is received. The first input medical image identifies a location of a point of interest. A set of features is extracted from each of the plurality of input medical images. Features between each of the sets of features are related using a machine learning based relational network. A location of the point of interest in each of the one or more additional input medical images that corresponds to the location of the point of interest in the first input medical image is identified based on the related features. The location of the point of interest in each of the one or more additional input medical images is output.

Abstract: At least one example embodiment provides a computer-implemented method for evaluating at least one image data set of an imaging region of a patient, wherein at least one evaluation information describing at least one medical condition in an anatomical structure of the imaging region is determined.

Abstract: Method and system for image registration or image segmentation. The method includes receiving an image which is to be processed by a first machine-learning model to perform, for example, image registration or segmentation, and using a second machine-learning model to determine if the received image is of a quality suitable for the first machine-learning model to act upon.