Patents by Inventor Seth A. Darst

Seth A. Darst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal of bacterial core RNA polymerase with rifampicin and methods of use thereof
    Publication number: 20040048350
    Abstract: A detailed three-dimensional structure of rifampicin bound to a core bacterial RNA polymerase (Rif-RNAP) is provided. Crystals of the Rif-RNAP are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Application
    Filed: March 9, 2001
    Publication date: March 11, 2004
    Inventors: Seth A. Darst, Elizabeth Campbell
  • Crystal of bacterial core RNA polymerase
    Publication number: 20020034808
    Abstract: A detailed three-dimensional structure for a bacterial core RNA polymerase is provided. Crystals of the bacterial core RNA polymerase are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Application
    Filed: February 13, 2001
    Publication date: March 21, 2002
    Inventors: Seth A. Darst, Gongyi Zhang, Elizabeth Campbell, Leonid Minakin, Konstantin Severinov
  • Crystal of bacterial core RNA polymerase and methods of use thereof
    Patent number: 6225076
    Abstract: A detailed three dimensional structure for a bacterial core RNA polymerase is provided. Crystals of the bacterial core RNA polymerase are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit bacterial proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Grant
    Filed: September 15, 1999
    Date of Patent: May 1, 2001
    Assignees: The Rockefeller University, Rutgers, the State University of New Jersey
    Inventors: Seth A. Darst, Gongyi Zhang, Elizabeth Campbell, Leonid Minakin, Konstantin Severinov