Patents by Inventor Seth Blackshaw

Seth Blackshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR USING ALTERNATIVE SPLICING TO CONTROL SPECIFICITY OF GENE THERAPY
    Publication number: 20240108756
    Abstract: Disclosed herein are compositions and methods that can be used to express a nucleotide sequence in a specific cell type. The compositions can comprise nucleic acid constructs comprising a start codon; and an intron cassette. The intron cassette can comprise a cell specific exon sequence, a splice donor site, a branch site, and an acceptor site. The cell specific exon sequence is out of frame with the start codon and comprises one or more frameshift mutations. The compositions can be used to treat human diseases.
    Type: Application
    Filed: October 16, 2020
    Publication date: April 4, 2024
    Inventors: Jonathan P. Ling, Seth Blackshaw
  • COMPOSITIONS AND METHODS FOR CELLULAR COMPONENT TRANSFER THERAPY
    Publication number: 20230272339
    Abstract: The present disclosure provides methods for generating retinal cell clusters for use in cellular component transfer therapy, retinal cell clusters generated by such methods, and compositions comprising such retinal cell clusters. The present disclosure also provides uses of the retinal cell clusters and compositions comprising thereof for preventing and/or treating inherited retinal degenerative diseases.
    Type: Application
    Filed: May 1, 2023
    Publication date: August 31, 2023
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Mandeep SINGH, Seth Blackshaw, Robert Johnston, Jiang Qian, Ying Liu
  • METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES
    Publication number: 20220363712
    Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.
    Type: Application
    Filed: June 6, 2022
    Publication date: November 17, 2022
    Inventors: Jef D. BOEKE, Heng ZHU, Seth BLACKSHAW, Daniel J. EICHINGER, Ignacio PINO
  • METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES
    Publication number: 20180030086
    Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.
    Type: Application
    Filed: June 23, 2017
    Publication date: February 1, 2018
    Inventors: Jef D. BOEKE, Heng ZHU, Seth BLACKSHAW, Daniel J. EICHINGER, Ignacio PINO
  • METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES
    Publication number: 20130288910
    Abstract: Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.
    Type: Application
    Filed: June 16, 2011
    Publication date: October 31, 2013
    Inventors: Jef D. Boeke, Heng Zhu, Seth Blackshaw, Daniel J. Eichinger, Ignacio Pino
  • Amiloride-sensitive sodium channel and method of identifying substances which stimulate or block salty taste perception
    Patent number: 5693756
    Abstract: An amiloride sensitive sodium channel (ENAC) has been localized to the epithelium of tongue, including taste tissue. This discovery provides a method of identifying substances which stimulate or block salty taste in mammals. Alternatively spliced forms have also been identified.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: December 2, 1997
    Assignee: The Johns Hopkins University
    Inventors: Xiao-Jiang Li, Seth Blackshaw, Solomon H. Snyder