Patents by Inventor Seth C. Alexander

Seth C. Alexander has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Guide RNAs Comprising an Internal Linker for Gene Editing
    Publication number: 20240150761
    Abstract: This disclosure relates to modified guide RNAs comprising an internal linker for in vitro and in vivo gene editing methods.
    Type: Application
    Filed: December 7, 2023
    Publication date: May 9, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Sabin Mulepati, Rubina Giare Parmar, Lindsey Jean Stretz, Michelle Young, Jasmine Josephine Bonanno, Seth C. Alexander
  • Compositions and Methods Comprising a TTR Guide RNA and a Polynucleotide Encoding an RNA-Guided DNA Binding Agent
    Publication number: 20240124897
    Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
    Type: Application
    Filed: July 31, 2023
    Publication date: April 18, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Yong Chang, Seth C. Alexander, Kristy M. Wood, Arti Mahendra Prakash Kanjolia, Shobu Odate, Jessica Lynn Seitzer, Reynald Michael Lescarbeau, Walter Strapps
  • Polynucleotides, Compositions, and Methods for Genome Editing
    Publication number: 20240076636
    Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.
    Type: Application
    Filed: April 7, 2023
    Publication date: March 7, 2024
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Christian Dombrowski, Jonathan Douglas Finn, Amy Madison Rhoden Smith, Seth C. Alexander
  • Polynucleotides, compositions, and methods for genome editing
    Patent number: 11697806
    Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: July 11, 2023
    Assignee: Intellia Therapeutics, Inc.
    Inventors: Christian Dombrowski, Jonathan Douglas Finn, Amy Madison Rhoden Smith, Seth C. Alexander
  • Compositions and Methods Comprising a TTR Guide RNA and a Polynucleotide Encoding an RNA-Guided DNA Binding Agent
    Publication number: 20230044994
    Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.
    Type: Application
    Filed: September 27, 2021
    Publication date: February 9, 2023
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Yong Chang, Seth C. Alexander, Kristy M. Wood, Arti Mahendra Prakash Kanjolia, Shobu Odate, Jessica Lynn Seitzer, Reynald Michael Lescarbeau, Walter Strapps
  • Compositions and Methods for TTR Gene Editing and Treating ATTR Amyloidosis Comprising a Corticosteroid or Use Thereof
    Publication number: 20230035659
    Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene in combination with administration of a corticosteroid are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), in which a guide RNA and a corticosteroid are administered, are provided.
    Type: Application
    Filed: September 27, 2021
    Publication date: February 2, 2023
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Yong CHANG, Seth C. ALEXANDER, Kristy M. WOOD, Arti Mahendra Prakash KANJOLIA, Shobu ODATE, Jessica Lynn SEITZER, Reynald Michael LESCARBEAU, Walter STRAPPS
  • Polynucleotides, Compositions, and Methods for Polypeptide Expression
    Publication number: 20230012687
    Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.
    Type: Application
    Filed: September 27, 2021
    Publication date: January 19, 2023
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Bradley Andrew Murray, Christian Dombrowski, Seth C. Alexander
  • Modified Guide RNAs for Gene Editing
    Publication number: 20220372483
    Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.
    Type: Application
    Filed: June 9, 2022
    Publication date: November 24, 2022
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Seth C. Alexander, Sabin Mulepati, Matthew Roy
  • Enzymatic modification of nucleic acids
    Patent number: 11267842
    Abstract: There are provided, inter alia, methods and reagents for labeling nucleic acids.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 8, 2022
    Assignee: The Regents of the University of California
    Inventors: Neal K. Devaraj, Seth C. Alexander
  • Modified Guide RNAs for Gene Editing
    Publication number: 20210087568
    Abstract: This disclosure relates to modified guide RNAs having improved in vitro and in vivo activity in gene editing methods.
    Type: Application
    Filed: December 4, 2020
    Publication date: March 25, 2021
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Amy Madison Rhoden Smith, Seth C. Alexander, Duncan Brown, Robert Brown, Adhiraj Lanba, Rebecca Lescarbeau, Reynald Michael Lescarbeau, Rubina Parmar, Matthew Roy, Paige Salerno, Jessica Lynn Seitzer
  • Polynucleotides, Compositions, and Methods for Genome Editing
    Publication number: 20200354702
    Abstract: Compositions and methods for gene editing. In some embodiments, a polynucleotide encoding Cas9 is provided that can provide one or more of improved editing efficiency, reduced immunogenicity, or other benefits.
    Type: Application
    Filed: March 24, 2020
    Publication date: November 12, 2020
    Applicant: Intellia Therapeutics, Inc.
    Inventors: Christian Dombrowski, Jonathan Douglas Finn, Amy Madison Rhoden Smith, Seth C. Alexander
  • ENZYMATIC MODIFICATION OF NUCLEIC ACIDS
    Publication number: 20180148764
    Abstract: There are provided, inter alia, methods and reagents for labeling nucleic acids.
    Type: Application
    Filed: March 3, 2016
    Publication date: May 31, 2018
    Inventors: Neal K. Devaraj, Seth C. Alexander