Patents by Inventor Seth C. Ennis

Seth C. Ennis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8299306
    Abstract: This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkyl-carbonyl group or a phenylcarbonyl group, or a salt thereof, comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R1(MgX)n—LiY wherein n is 1 or 2; R1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (IV) wherein A is a linear, branched or cyclic C1-C6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: October 30, 2012
    Inventors: Seth C. Ennis, Bryan D. Kennedy
  • Patent number: 8115028
    Abstract: The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: February 14, 2012
    Inventors: Seth C. Ennis, Cornelia Fuchs, Ralf Kanzler, Dean A. Johnson
  • Patent number: 7985873
    Abstract: The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: July 26, 2011
    Assignee: UCB Pharma GmbH
    Inventors: Seth C. Ennis, Roland Drews, Claus Meese
  • Publication number: 20100292499
    Abstract: The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, characterized by the steps of reacting a compound of formula (II) with a mixture of Grignard initiator and Mg in a solvent to form a Grignard reagent, reacting the Grignard reagent with paraformaldehyde or trioxane to obtain a compound of formula (III) and then further reacting the compound of formula (III) in a known manner to obtain a compound of formula (I) and optionally salt formation.
    Type: Application
    Filed: June 5, 2007
    Publication date: November 18, 2010
    Applicant: SCHWARZ PHARMA LTD.
    Inventors: Seth C. Ennis, Cornelia Fuchs, Ralf Kanzler, Dean A. Johnson
  • Publication number: 20100174107
    Abstract: This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkyl-carbonyl group or a phenylcarbonyl group, or a salt thereof, comprising the following steps: a) adding to a suspension of Mg a compound of formula (II) R1(MgX)n—LiY wherein n is 1 or 2; R1 is an aromatic, aliphatic, carbocyclic or heterocyclic organic group having 1 to 24 carbon atoms; X and Y are independently selected from Cl, Br and I, b) reacting said reaction mixture with a suitable halogenated compound in a solvent to form a Grignard reagent, c) reacting said Grignard reagent with a suitable linear, branched or cyclic carbonate to obtain a compound of formula (TV) wherein A is a linear, branched or cyclic C1-C6 alkyl group, and preferably a methyl group, and then further reacting the compound of formula (IV) in a known manner to obtain a compound of formula (I) and optionally salt formation.
    Type: Application
    Filed: June 4, 2007
    Publication date: July 8, 2010
    Applicant: SCHWARZ PHARMA LTD.
    Inventors: Seth C. Ennis, Bryan D. Kennedy
  • Publication number: 20100168459
    Abstract: The present invention provides a process for the production of a compound of formula (I) or a salt thereof, wherein R is hydrogen, a straight, branched or cyclic C1-C6 alkyl group or an aryl group which may optionally be substituted. This process comprises: (a) reacting a compound of formula (II), with a compound of formula (III), wherein R is as defined above and X is a leaving group, in the presence of N,N-di-isopropylethylamine.
    Type: Application
    Filed: June 5, 2007
    Publication date: July 1, 2010
    Applicant: SCHWARZ PHARMA LTD.
    Inventors: Seth C. Ennis, Roland Drews, Claus Meese