Abstract: Compositions and methods for editing, e.g., introducing double-stranded breaks, within the TTR gene are provided. Compositions and methods for treating subjects having amyloidosis associated with transthyretin (ATTR), are provided.

Abstract: A recessed LED light fixture without need for a bulky, finned, metal heat sink. The recessed LED light fixture includes a Metal Core Printed Circuit Board (MCPCB) holding an array of LEDs that are arrange at the center thereof, and mounted to the printed circuit board using patterns of electrical and greases used to conduct a current and radiate heat. A mounting bracket holds the entire assembly for the light fixture together while spacing the LED driver and printed circuit board apart for further cooling, and wherein the upper side of the printed circuit board is exposed to the ambient air inside the housing.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting plate that includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting plate that includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: A recessed LED light fixture without need for a bulky, finned, metal heat sink. The recessed LED light fixture includes a Metal Core Printed Circuit Board (MCPCB) holding an array of LEDs that are arrange at the center thereof, and mounted to the printed circuit board using patterns of electrical and greases used to conduct a current and radiate heat. A mounting bracket holds the entire assembly for the light fixture together while spacing the LED driver and printed circuit board apart for further cooling, and wherein the upper side of the printed circuit board is exposed to the ambient air inside the housing.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting plate that includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: A recessed LED light fixture without need for a bulky, finned, metal heat sink. The recessed LED light fixture includes a Metal Core Printed Circuit Board (MCPCB) holding an array of LEDs that are arrange at the center thereof, and mounted to the printed circuit board using patterns of electrical and thermal conductors used to conduct a current and radiate heat. A mounting bracket holds the entire assembly for the light fixture together while spacing the LED driver and printed circuit board apart for further cooling, and wherein the upper side of the printed circuit board is exposed to the ambient air inside the housing.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting plate that includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting plate that includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: A solid state, recessed light fixture for residential and commercial lighting applications. The fixture includes a truncated cone-shaped trim having a concave bottom surface and a convex top surface, wherein the trim has a sloped circumferential wall that leads to a flat, annular lip at its periphery. An LED array is mounted to the underside within the concave bottom surface and a LED driver is mounted to the top surface. A cover with an open bottom partially encloses the LED driver and a junction box with cable openings and knock out ports is stacked on top of the cover. The cover is a thermal insulator to contain heat from the LED driver inside while the trim acts as a thermal conductor and radiator for the LED driver. No “can” housing is needed to enclose the fixture, and no finned, heat sink is needed to dissipate heat.

Abstract: An LED light module assembly for a light fixture is disclosed. The LED light module assembly includes a light source having a printed circuit board containing an LED driver and LEDs. The printed circuit board is directly attached to a mounting board includes a thermally conductive and radiating material. An LED cover overlies the LEDs. Spring retainer clips hold a decorative trim ring in a spaced-apart relationship from the mounting plate, creating an air gap for cooling and keeping the trim ring cool. A light diffuser lens has hooked legs that twist lock to the mounting plate and diffuses the light from the LEDs.

Abstract: A recessed LED light fixture without need for a bulky, finned, metal heat sink. The recessed LED light fixture includes a Metal Core Printed Circuit Board (MCPCB) holding an array of LEDs that are arrange at the center thereof, and mounted to the printed circuit board using patterns of electrical and thermal conductors used to conduct a current and radiate heat. A mounting bracket holds the entire assembly for the light fixture together while spacing the LED driver and printed circuit board apart for further cooling, and wherein the upper side of the printed circuit board is exposed to the ambient air inside the housing.

Abstract: A solid state, recessed light fixture for residential and commercial lighting applications. The fixture includes a truncated cone-shaped trim having a concave bottom surface and a convex top surface, wherein the trim has a sloped circumferential wall that leads to a flat, annular lip at its periphery. An LED array is mounted to the underside within the concave bottom surface and a LED driver is mounted to the top surface. A cover with an open bottom partially encloses the LED driver and a junction box with ROMEX® cable openings and knock out ports is stacked on top of the cover. The cover is a thermal insulator to contain heat from the LED driver inside while the trim acts as a thermal conductor and radiator for the LED driver. No “can” housing is needed to enclose the fixture, and no finned, heat sink is needed to dissipate heat.

Abstract: A recessed LED ceiling light fixture kit for installation to a ceiling panel or plaster frame in residential homes or commercial buildings is disclosed. The kit includes an LED engine with at least one LED facing downward, an LED driver, and an annular shaped, finned heat sink that receives the LED driver therein and the LED underneath. The fixture includes a tubular-shaped can having an open bottom and a top engaging the heat sink. Detachable can retainer springs or threaded fasteners engage the can at its circumference, wherein the springs mount the can to the ceiling panel, or alternatively, the fasteners attach the can to the plaster frame. A trim ring is snapped onto the can at its open bottom, and an electrical junction box sits on top of the heat sink.

Abstract: A recessed lighting fixture providing illumination from a light source including a plurality of light emitting diodes (LEDs) wherein the fixture is placed within the ceiling space above a ceiling panel or wall. The fixture has a low aspect ratio heat sink. An interchangeable trim ring has an integrated light reflector and attaches to the bottom of the heat sink via rare earth or super magnets. A flange of the heat sink and a flat annular surface of the trim ring engage each other, providing a large contact surface to enable conductive heat transfer. The flange and flat annular surface are located below the ceiling panel, which is at room temperature to help cool the recessed LED lighting fixture through radiation and air convection.

Abstract: A recessed lighting fixture providing illumination from a light source including a plurality of light emitting diodes (LEDs) wherein the fixture is placed within the ceiling space above a ceiling panel or wall. The fixture has a low aspect ratio heat sink. An interchangeable trim ring has an integrated light reflector and attaches to the bottom of the heat sink via rare earth or super magnets. A flange of the heat sink and a flat annular surface of the trim ring engage each other, providing a large contact surface to enable conductive heat transfer. The flange and flat annular surface are located below the ceiling panel, which is at room temperature to help cool the recessed LED lighting fixture through radiation and air convection.

Abstract: A recessed ceiling light fixture with spring biased retainer clips that retract flush or are biased away from the side of the can housing for installation is disclosed. The fixture includes a housing having a side wall, a top wall, and an open bottom. Two rigid retainer clips are mounted diametrically opposed on the housing. Each retainer clip has a mounting tab inside the housing extending into a leg that passes out of the housing, which leg is bent to form an elbow, which elbow extends to a strut passing back into the housing, wherein the mounting tab selectively engages the side wall to limit movement of the spring clip. A bolt and coiled spring create compliance and bias in the spring clip by passing loosely through a slotted opening in the top wall at one end and joining the mounting tab at the other end.

Abstract: A recessed LED ceiling light fixture kit for installation to a ceiling panel or plaster frame in residential homes or commercial buildings is disclosed. The kit includes an LED engine with at least one LED facing downward, an LED driver, and an annular shaped, finned heat sink that receives the LED driver therein and the LED underneath. The fixture includes a tubular-shaped can having an open bottom and a top engaging the heat sink. Detachable can retainer springs or threaded fasteners engage the can at its circumference, wherein the springs mount the can to the ceiling panel, or alternatively, the fasteners attach the can to the plaster frame. A trim ring is snapped onto the can at its open bottom, and an electrical junction box sits on top of the heat sink.

Abstract: A recessed ceiling light fixture with spring biased retainer clips that retract flush or are biased away from the side of the can housing for installation is disclosed. The fixture includes a housing having a side wall, a top wall, and an open bottom. Two rigid retainer clips are mounted diametrically opposed on the housing. Each retainer clip has a mounting tab inside the housing extending into a leg that passes out of the housing, which leg is bent to form an elbow, which elbow extends to a strut passing back into the housing, wherein the mounting tab selectively engages the side wall to limit movement of the spring clip. A bolt and coiled spring create compliance and bias in the spring clip by passing loosely through a slotted opening in the top wall at one end and joining the mounting tab at the other end.

Abstract: An adjustable mobile base includes a closed loop frame which has a plurality of angled members and a plurality of tubular connectors interconnecting the angled members. Each of the angled members is formed with a corner and has two tube sections. Each of the tube sections is formed with a plurality of spaced first engaging through holes which extends in the direction of a longitudinal axis of the tube section. Each of the angled members further has a triangular support plate secured on the corner. Each of the tubular connectors has two ends slidably inserted into a respective one of the tube sections of the angled members. Each of the tubular connectors is formed with a plurality of spaced second engaging through holes which are aligned with the first engaging through holes. A plurality of locking bolt units respectively extend through the aligned first and second through holes so as to join the tubular connectors and the angled members.