Abstract: A fluidic connection system includes a threaded fastener and a fitting assembly. The threaded fastener may be a universal threaded fastener that may be used with various tubings having different outer diameters. The fitting assembly includes a locking ring and a ferrule sized and shaped to fit within a borehole of the locking ring. When the fluidic connection system is assembled an end of the locking ring and an end of the ferrule project beyond an end of the fitting assembly. In some embodiments, the locking ring may be symmetric about a plane normal to its longitudinal axis such that the locking ring may be positioned on the tubing in either direction. The locking ring may be received in a fitting pocket of the fitting assembly. In other embodiments, the locking ring has a tapered feature on an end that engages with a tapered feature on the threaded fastener for aiding in centering the locking ring within the threaded fastener.