Patents by Inventor Seth Koehler

Seth Koehler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR ADMINISTERING OTOFERLIN DUAL VECTOR SYSTEMS
    Publication number: 20240309399
    Abstract: The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with a mutation in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF protein (e.g., an OTOF isoform 5 protein) and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF protein (e.g., an OTOF isoform 5 protein). These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.
    Type: Application
    Filed: February 16, 2024
    Publication date: September 19, 2024
    Inventors: Qi-Ying HU, Orion Paul Keifer, JR., Seth Koehler, John Lee, Adam Palermo, Ning Pan, Jonathan B. Sellon, Jonathon Whitton
  • Personalized auditory-somatosensory stimulation to treat tinnitus
    Patent number: 10569082
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: February 25, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan Shore, David Martel, Seth Koehler
  • PERSONALIZED AUDITORY-SOMATOSENSORY STIMULATION TO TREAT TINNITUS
    Publication number: 20170281900
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Application
    Filed: June 19, 2017
    Publication date: October 5, 2017
    Inventors: Susan Shore, David Martel, Seth Koehler
  • Personalized auditory-somatosensory stimulation to treat tinnitus
    Patent number: 9682232
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: June 20, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan Shore, David Martel, Seth Koehler
  • PERSONALIZED AUDITORY-SOMATOSENSORY STIMULATION TO TREAT TINNITUS
    Publication number: 20160106975
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Application
    Filed: December 21, 2015
    Publication date: April 21, 2016
    Inventors: Susan Shore, David Martel, Seth Koehler
  • Personalized auditory-somatosensory stimulation to treat tinnitus
    Patent number: 9242067
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: January 26, 2016
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan Shore, David Martel, Seth Koehler
  • PERSONALIZED AUDITORY-SOMATOSENSORY STIMULATION TO TREAT TINNITUS
    Publication number: 20140275737
    Abstract: Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Susan Shore, David Martel, Seth Koehler