Patents by Inventor Seth Lawler Shipman

Seth Lawler Shipman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Systems of Molecular Recording by Crispr-Cas System
    Publication number: 20230212563
    Abstract: This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, wherein the cell expresses the Cas1 protein and/or the Cas2 protein and wherein the CRISPR array nucleic acid sequence is within genomic DNA of the cell or on a plasmid. Also provided are methods and systems for nucleic acid storage and in vivo molecular recordings of events into a cell.
    Type: Application
    Filed: April 11, 2022
    Publication date: July 6, 2023
    Inventors: George M. Church, Seth Lawler Shipman, Jeffrey D. Macklis, Jeffrey Matthew Nivala
  • Methods and systems of molecular recording by CRISPR-Cas system
    Patent number: 11326161
    Abstract: This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, wherein the cell expresses the Cas1 protein and/or the Cas2 protein and wherein the CRISPR array nucleic acid sequence is within genomic DNA of the cell or on a plasmid. Also provided are methods and systems for nucleic acid storage and in vivo molecular recordings of events into a cell.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: May 10, 2022
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Seth Lawler Shipman, Jeffrey D. Macklis, Jeffrey Matthew Nivala
  • METHODS AND SYSTEMS OF MOLECULAR RECORDING BY CRISPR-CAS SYSTEM
    Publication number: 20210230588
    Abstract: This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, wherein the cell expresses the Cas1 protein and/or the Cas2 protein and wherein the CRISPR array nucleic acid sequence is within genomic DNA of the cell or on a plasmid. Also provided are methods and systems for nucleic acid storage and in vivo molecular recordings of events into a cell.
    Type: Application
    Filed: February 16, 2017
    Publication date: July 29, 2021
    Inventors: George M. Church, Seth Lawler Shipman, Jeffrey D. Manklis, Jeffrey Matthew Nivala
  • Method of Off-Target Recording of Spacer Sequences within a Cell In Vivo
    Publication number: 20200190534
    Abstract: This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a consensus CRISPR array nucleic acid sequence including a leader sequence and at least one consensus repeat sequence, and wherein the cell expresses the Cas1 protein and/or the Cas2 protein.
    Type: Application
    Filed: April 27, 2018
    Publication date: June 18, 2020
    Inventors: Jeffrey Matthew Nivala, Seth Lawler Shipman, George M. Church
  • Method of Recording Multiplexed Biological Information into a CRISPR Array Using a Retron
    Publication number: 20200115706
    Abstract: This invention provides methods of altering a cell including providing the cell with a nucleic acid sequence encoding a Cas1 protein and/or a Cas2 protein of a CRISPR adaptation system, providing the cell with a CRISPR array nucleic acid sequence including a leader sequence and at least one repeat sequence, and providing the cell with one or more retron systems, wherein the cell expresses the Cas1 protein and/or the Cas2 protein.
    Type: Application
    Filed: April 12, 2018
    Publication date: April 16, 2020
    Inventors: Seth Lawler Shipman, Jeffrey Matthew Nivala, George M. Church, Max Schubert