Patents by Inventor Seth Stern
Seth Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220186303Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.Type: ApplicationFiled: July 23, 2021Publication date: June 16, 2022Inventors: Hesaam Esfandyarpour, Maryam Jouzi, Seth Stern, Paul Kenney
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Patent number: 10900075Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.Type: GrantFiled: September 25, 2018Date of Patent: January 26, 2021Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Maryam Jouzi, Seth Stern, Paul Kenney
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Publication number: 20200232024Abstract: Provided herein are systems and methods for processing and analyzing nucleic acids and other biomolecules. Methods may include processing nucleic acid molecules in an emulsion of droplets. Methods of analyzing nucleic acid molecules may include coupling nucleic acids to a bead or other support. Methods may include analysis of nucleic acid molecules using a redox mediator. In some cases, analysis of the nucleic acid molecule includes determining a nucleotide sequence of the nucleic acid molecule.Type: ApplicationFiled: December 12, 2019Publication date: July 23, 2020Inventors: Hesaam Esfandyarpour, Kosar Parizi, Saurabh Paliwal, Seth Stern, Paul Kenney, Meysam R. Barmi, Ali Nabi, Hamid Rategh
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Publication number: 20200206736Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: ApplicationFiled: August 7, 2019Publication date: July 2, 2020Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Patent number: 10544456Abstract: Provided herein are systems and methods for processing and analyzing nucleic acids and other biomolecules. Methods may include processing nucleic acid molecules in an emulsion of droplets. Methods of analyzing nucleic acid molecules may include coupling nucleic acids to a bead or other support. Methods may include analysis of nucleic acid molecules using a redox mediator. In some cases, analysis of the nucleic acid molecule includes determining a nucleotide sequence of the nucleic acid molecule.Type: GrantFiled: July 20, 2017Date of Patent: January 28, 2020Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Kosar Parizi, Saurabh Paliwal, Seth Stern, Paul Kenney, Meysam R. Barmi, Ali Nabi, Hamid Rategh
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Patent number: 10413900Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: GrantFiled: December 15, 2016Date of Patent: September 17, 2019Assignee: GENAPSYS, INC.Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Publication number: 20190256903Abstract: The present disclosure provides methods and systems for sequencing nucleic acid molecules. Methods may include sequencing double-stranded nucleic acids or single-stranded nucleic acids. Sequencing may include the use of nucleotides coupled to electrostatic moieties. The electrostatic moieties may be detected by a sensor array. The electrostatic moieties may be reversible electrostatic moieties that are cleaved from the nucleic acid molecule after incorporation of the nucleotide. The electrostatic moieties may be irreversible electrostatic moieties. Nucleotides comprising irreversible electrostatic moieties may be incorporated into the nucleic acid molecule, detected by the sensor array, and exchanged for non-detectable nucleotides.Type: ApplicationFiled: September 25, 2018Publication date: August 22, 2019Inventors: Hesaam Esfandyarpour, Maryam Jouzi, Seth Stern, Paul Kenney
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Publication number: 20190241951Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.Type: ApplicationFiled: September 20, 2018Publication date: August 8, 2019Inventors: Hesaam Esfandyarpour, Meysam R. Baemi, kosar B. Parizi, Saurabh Paliwal, Amirhossein Samakar, Seth Stern
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Patent number: 10125393Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.Type: GrantFiled: December 10, 2014Date of Patent: November 13, 2018Assignee: GENAPSYS, INC.Inventors: Hesaam Esfandyarpour, Meysam R. Barmi, Kosar B. Parizi, Saurabh Paliwal, Amirhossein Samakar, Seth Stern
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Publication number: 20180100190Abstract: Provided herein are systems and methods for processing and analyzing nucleic acids and other biomolecules. Methods may include processing nucleic acid molecules in an emulsion of droplets. Methods of analyzing nucleic acid molecules may include coupling nucleic acids to a bead or other support. Methods may include analysis of nucleic acid molecules using a redox mediator. In some cases, analysis of the nucleic acid molecule includes determining a nucleotide sequence of the nucleic acid molecule.Type: ApplicationFiled: July 20, 2017Publication date: April 12, 2018Inventors: Hesaam Esfandyarpour, Aldrich N.K. Lau, Kosar Parizi, Saurabh Paliwal, Henrik Persson, Seth Stern, Paul Kenney, Meysam R. Barmi, Ali Nabi, Hamid Rategh, Florian Oberstrass
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Patent number: 9731266Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.Type: GrantFiled: July 21, 2015Date of Patent: August 15, 2017Assignee: IntegenX Inc.Inventors: Seth Stern, Stevan B. Jovanovich
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Patent number: 9630177Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: GrantFiled: March 12, 2015Date of Patent: April 25, 2017Assignee: GenapSys, Inc.Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Publication number: 20170096705Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: ApplicationFiled: December 15, 2016Publication date: April 6, 2017Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Publication number: 20160273032Abstract: Provided herein are devices and methods suitable for sequencing, detecting, amplifying, analyzing, and performing sample preparation procedures for nucleic acids and other molecules. In some cases, the devices and methods provided herein are used for computation.Type: ApplicationFiled: December 10, 2014Publication date: September 22, 2016Applicant: GENAPSYS, INC.Inventors: Hesaam ESFANDYARPOUR, Meysam R. BARMI, Kosar B. PARIZI, Saurabh PALIWAL, Amirhossein SAMAKAR, Seth STERN
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Publication number: 20160016140Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.Type: ApplicationFiled: July 21, 2015Publication date: January 21, 2016Applicant: INTEGENX INC.Inventors: Stevan B. Jovanovich, Seth Stern, Ezra Van Gelder, Mattias Vangbo
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Publication number: 20150258544Abstract: The present disclosure provides microfluidic devices, systems and methods for sample preparation and/or analysis. A microfluidic device can include a first channel having a sequence of (n) chambers each having a first volume (v). The first channel can include one or more valves at opposing ends of the first channel that fluidically isolate the first channel. The microfluidic device can further include a second channel in fluid communication with the first channel. The second channel can include at least one second chamber having a total second volume that is at least equal to the total volume of the first channel (n*v). The second channel can include one or more valves at opposing ends of the second channel that fluidically isolate the second channel from the first channel.Type: ApplicationFiled: March 12, 2015Publication date: September 17, 2015Inventors: Seth Stern, Hesaam Esfandyarpour, David Eberhart
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Patent number: 9121058Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.Type: GrantFiled: August 20, 2011Date of Patent: September 1, 2015Assignee: IntegenX Inc.Inventors: Seth Stern, Stevan Bogdan Jovanovich
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Publication number: 20140370519Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The cartridges, microchips, and pneumatic manifolds can be integrated with downstream preparation devices, such as thermal regulating devices and separation and analysis devices.Type: ApplicationFiled: April 15, 2014Publication date: December 18, 2014Applicant: IntegenX Inc.Inventors: Mattias Vangbo, William D. Nielsen, Iuliu Iouan Blaga, Seth Stern, Joanne Horn, Michael Van Nguyen, Stevan Jovanovich
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Publication number: 20130203634Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.Type: ApplicationFiled: August 20, 2011Publication date: August 8, 2013Applicant: INTEGENX INC.Inventors: Stevan B. Jovanovich, Seth Stern, Ezra Van Gelder, Mattias Vangbo
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Publication number: 20120164036Abstract: The invention provides for devices and methods for interfacing microchips to cartridges and pneumatic manifolds. The design of the cartridges, microchips, and pneumatic manifolds can allow for the use of magnetic forces to capture magnetic beads in a chamber formed between the microchip and the cartridge or a chamber within the microchip. The devices of the invention can be used for mRNA amplification and purification.Type: ApplicationFiled: June 29, 2010Publication date: June 28, 2012Inventors: Seth Stern, Greg Bogdan, David Eberhart