Abstract: A medicated intrauterine device insertable in and retained in the uterus for a predetermined time period and having a drug with a controlled release rate and said drug comprising an amiedine or a guanidine such as an aromatic monoamidine or a monoguanidine, an aromatic diamidine or a diguanidine, a non-aromatic monoguanidine or a non-aromatic diamidine or a diguanidine to provide anti-fibrinolytic, anti-proteolytic and/or anti-conceptive action. The drug is one or a mixture of more than one of such amidines or guanidines, or a mixture of one or more of such guanidines with one or more amidines.

Abstract: A medicated intrauterine device insertable in and retained in the uterus for a predetermined time period and having a drug with a controlled release rate and said drug comprising a guanidine such as an aromatic monoguanidine, an aromatic diguanidine, a non-aromatic monoguanidine or a non-aromatic diguanidine to provide anti-fibrinolytic, anti-proteolytic and/or anti-conceptive action. The drug is one or a mixture of more than one of such guanidines, or a mixture of one or more of such guanidines with one or more amidines.

Abstract: A medicated intrauterine device insertable in and retained in the uterus for a predetermined time period and having a drug with a controlled release rate and said drug comprising a guanidine such as an aromatic monoguanidine, an aromatic diguanidine, a non-aromatic monoguanidine or a non-aromatic diguanidine to provide anti-fibrinolytic, anti-proteolytic and/or anti-conceptive action. The drug is one or a mixture of more than one of such guanidines, or a mixture of one or more of such guanidines with one or more amidines.

Abstract: An intrauterine device of the type having an external surface contacting the walls of the uterus after insertion therein, and said device having first walls defining a fluid-receiving cavity in at least a portion thereof. A concentrated fluid solution of a drug is present in the cavity and the drug is of the type providing an antifibrinolytic, an antifertility and antiproteolytic effect and is one or a mixture of more than one guanidine such as any aromatic monoguanidine, aromatic diguanidine, non-aromatic monoguanidine and non-aromatic diguanidine, and mixtures of one or more of the guanidines with one or more amidines.

Abstract: An intrauterine device of the type having an external surface contacting the walls of the uterus after insertion therein, and said device having first walls defining a fluid receiving cavity in at least a portion thereof. A concentrated fluid solution of a drug is present in the cavity and the drug is of the type providing an antifertility and antiproteolytic effect and is selected from the group consisting of aromatic monoamidines, aromatic diamidines and non-aromatic diamidines.