Patents by Inventor Seth Winfree

Seth Winfree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantitative liquid biopsy diagnostic system and methods
    Patent number: 12613190
    Abstract: The present invention provides a quantitative liquid biopsy diagnostic system and methods for performing diagnostic assays. The system offers a liquid biopsy method using circulating tumor cells (CTCs) or White Blood Cells (WBC) subpopulations for precision cancer diagnosis, early detection of disease evolution, and cancer patient management. The invention utilizes selective plane illumination microscopy (SPIM) to deliver high sensitivity and specificity for the detection and isolation of individual CTCs, superseding the efficacy of existing methodologies for early cancer detection. Isolated CTCs can be analyzed for their molecular fingerprint, which can lead to matching genetic abnormalities with specific drug treatments. The system allows ex vivo observation of live CTC or WBC response to treatment.
    Type: Grant
    Filed: June 27, 2018
    Date of Patent: April 28, 2026
    Assignee: QCDX LLC
    Inventors: Triantafyllos P. Tafas, Seth Winfree
  • BIOLOGICAL SAMPLE HOLDER AND HANDLER
    Publication number: 20240375114
    Abstract: The present invention provides a biological sample holder and handler system for cell-based liquid biopsies. The system is useful for performing diagnostic assays, based on a simple blood sample.
    Type: Application
    Filed: December 26, 2023
    Publication date: November 14, 2024
    Inventors: Triantafyllos P. Tafas, Seth Winfree, Scott W. Reed
  • BIOLOGICAL SAMPLE HOLDER AND HANDLER
    Publication number: 20210252518
    Abstract: The present invention provides a biological sample holder and handler system for cell-based liquid biopsies. The system is useful for performing diagnostic assays, based on a simple blood sample.
    Type: Application
    Filed: December 23, 2020
    Publication date: August 19, 2021
    Inventors: Triantafyllos P. Tafas, Seth Winfree, Scott W. Reed
  • QUANTITATIVE LIQUID BIOPSY DIAGNOSTIC SYSTEM AND METHODS
    Publication number: 20210018441
    Abstract: The present invention provides a quantitative liquid biopsy diagnostic system and methods for performing diagnostic assays. The system offers a liquid biopsy method using circulating tumor cells (CTCs) or White Blood Cells (WBC) subpopulations for precision cancer diagnosis, early detection of disease evolution, and cancer patient management. The invention utilizes selective plane illumination microscopy (SPIM) to deliver high sensitivity and specificity for the detection and isolation of individual CTCs, superseding the efficacy of existing methodologies for early cancer detection. Isolated CTCs can be analyzed for their molecular fingerprint, which can lead to matching genetic abnormalities with specific drug treatments. The system allows ex vivo observation of live CTC or WBC response to treatment.
    Type: Application
    Filed: June 27, 2018
    Publication date: January 21, 2021
    Inventors: Triantafyllos P. Tafas, Seth Winfree