Abstract: A composite lumen includes a braided structure infused with an impermeable elastic sealer. The braided structure has an inner diameter of 3 mm or less and a braid angle greater than 100°. The braided structure also has a wall thickness to inner diameter ratio greater than 0.02, picks per inch from between about 25 and about 135, and a number of ends between about 12 and about 48, with a braid pattern that is selected from 1×1, 2×2, or 2×1 and with an effective yarn denier (yarn denier×ply number) greater than 45.

Abstract: A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester.

Abstract: A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.

Abstract: A bioreactor system includes a bioreactor container having a first compartment, a second compartment, a first membrane separating the first compartment from the second compartment, a third compartment, and a second membrane separating the third compartment from the first compartment or the second compartment and the system further includes a tissue scaffold integrated with the bioreactor container in the second compartment to form a single bioreactor unit. One or more fluids can be added to one or more of the compartments.

Abstract: A textile engineered prosthetic includes a continuous tube and at least one band of increased thickness formed over a portion of the continuous tube. The continuous tube includes a body portion and a bifurcated portion. The band of increased thickness forms a biomimetic surface. A bioreactor system includes a bioreactor container including a first compartment, a second compartment, a first membrane separating the first and second compartments, a third compartment, and a second membrane separating the second and third compartments. The bioreactor system also includes a woven textile prosthetic integrated with the bioreactor container in the second compartment to form a single bioreactor unit. A furcated textile article includes a continuous tube having a body portion and a furcated portion bifurcated N times from the body portion. The furcated textile article is a continuous woven piece formed from N shuttles of a shuttle loom, where N is at least two.

Abstract: The disclosure describes textiles for endovascular and other medical applications having a low-profile and varying density. The textiles are woven and are formed of a non-uniform construction. The resulting textiles have a low profile and areas of targeted density to enhance ingrowth of regenerative tissue.

Abstract: A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester.

Abstract: A composite lumen includes an extruded tube of a composite including a poly(glycerol sebacate) (PGS) matrix mixed with a PGS thermoset filler. The composite lumen also includes an overbraid structure overlying an outer surface of the extruded tube. A method of forming a composite lumen includes extruding a PGS tube of a composite including a PGS matrix mixed with a PGS thermoset filler. The method also includes applying an overbraid structure over an outer surface of the extruded tube.

Abstract: A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester.

Abstract: A tubular woven implantable graft having a tapered section is provided. The graft includes a first diameter and a second diameter and has a generally constant number of warp yarns per inch adjacent both the first diameter and the second diameter. A method for producing an implantable woven graft is also provided. The method includes weaving a first section having a first diameter and a tapered diameter tapering from the first diameter to a second diameter. During weaving of the tapered section a number of warp yarns are dropped from the weave and compressive forces are applied to the fabric to narrow the width of the fabric.

Abstract: A tubular woven implantable graft having a tapered section is provided. The graft comprises a first diameter and a second diameter and has a generally constant number of warp yarns per inch adjacent both the first diameter and the second diameter. A method for producing an implantable woven graft is also provided. The method includes weaving a first section having a first diameter and a tapered diameter tapering from the first diameter to a second diameter. During weaving of the tapered section a number of warp yarns are dropped from the weave and compressive forces are applied to the fabric to narrow the width of the fabric.

Abstract: Woven textiles and methods of making woven textiles provide an increased level of three-dimensional design flexibility without extensive post weaving processing. Textiles are woven to form three-dimensional shaped structures, the shapes corresponding to anatomical and other designed structures. Hollow and/or expandable woven textiles with treads or filaments integrated into the construction, wherein the weft threads pass between or interchange between layers or folded layers, define a predetermined controlled shape and retain overall control of the form and size of the woven textile when expanded.

Abstract: A textile engineered prosthetic includes a continuous tube and at least one band of increased thickness formed over a portion of the continuous tube. The continuous tube includes a body portion and a bifurcated portion. The band of increased thickness forms a biomimetic surface. A bioreactor system includes a bioreactor container including a first compartment, a second compartment, a first membrane separating the first and second compartments, a third compartment, and a second membrane separating the second and third compartments. The bioreactor system also includes a woven textile prosthetic integrated with the bioreactor container in the second compartment to form a single bioreactor unit. A furcated textile article includes a continuous tube having a body portion and a furcated portion bifurcated N times from the body portion. The furcated textile article is a continuous woven piece formed from N shuttles of a shuttle loom, where N is at least two.

Abstract: A tubular woven implantable graft having a tapered section is provided. The graft comprises a first diameter and a second diameter and has a generally constant number of warp yarns per inch adjacent both the first diameter and the second diameter. A method for producing an implantable woven graft is also provided. The method includes weaving a first section having a first diameter and a tapered diameter tapering from the first diameter to a second diameter. During weaving of the tapered section a number of warp yarns are dropped from the weave and compressive forces are applied to the fabric to narrow the width of the fabric.

Abstract: A composite hollow lumen and a method for producing the lumen are provided. The lumen includes a tubular textile formed of yarns having a first tensile strength and a matrix material in which the tubular textile is embedded to form a conduit having a bore and a sidewall substantially impermeable to liquid. The matrix material has a second tensile strength that is lower than the first tensile strength. The method for producing a composite lumen includes selecting yarns having a first tensile strength, selecting an elastomeric matrix material having a second tensile strength that is lower that the first tensile strength, forming a tubular textile of the yarns, and embedding the tubular textile in the matrix material to form a conduit having a bore and conduit walls that are substantially impermeable to liquid. The elastomeric matrix material is a biodegradable or bioresorbable polyester.

Abstract: A tubular woven implantable graft having a tapered section is provided. The graft comprises a first diameter and a second diameter and has a generally constant number of warp yarns per inch adjacent both the first diameter and the second diameter. A method for producing an implantable woven graft is also provided. The method includes weaving a first section having a first diameter and a tapered diameter tapering from the first diameter to a second diameter. During weaving of the tapered section a number of warp yarns are dropped from the weave and compressive forces are applied to the fabric to narrow the width of the fabric.