Patents by Inventor Setsuko Mino
Setsuko Mino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6096746Abstract: An indazole compound having a piperazinyl moiety in the structure thereof, which is a 5-HT.sub.4 receptor agonist which is useful in the treatment of digestive tract disorders.Type: GrantFiled: March 23, 1999Date of Patent: August 1, 2000Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Masashi Suzuki, Masahiro Ueno, Ryuta Fukutomi, Hiroaki Satoh, Haruhiko Kikuchi, Koichiro Hagihara, Takeo Arai, Sugure Taniguchi, Setsuko Mino, Yumiko Noguchi
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Patent number: 5945434Abstract: An indazole compound having the formula (I): wherein:R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or C.sub.3 -C.sub.6 cycloalkyl;Q is carbonyl, thiocarbonyl or methylene; andR.sub.2 is a group of the formula (II) or (IV); ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.6 alkenyl or benzyl, of which a phenyl group thereof is optionally mono- or di-substituted by the same or different halogen or methoxy; m is 0 to 2; n and o is 1 or 2. The compound exhibits 5-HT.sub.4 receptor agonist activity.Type: GrantFiled: November 28, 1997Date of Patent: August 31, 1999Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Masashi Suzuki, Masahiro Ueno, Ryuta Fukutomi, Hiroaki Satoh, Haruhiko Kikuchi, Koichiro Hagihara, Takeo Arai, Sugure Taniguchi, Setsuko Mino, Yumiko Noguchi
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Patent number: 5753654Abstract: Novel diaminomethylidene derivatives represented by formula (I) ##STR1## wherein R.sup.1 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group and others, R.sup.2 is a group of the following formula ##STR2## and others, R.sup.3 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group and others, X is O, S, CHNO.sub.2, C(COOR.sup.4).sub.2, C(COOR.sup.4)CN or C(CN).sub.2) or pharmacologically acceptable salts thereof.The above-mentioned compounds are useful as a gastrointestinal prokinetic agent to be used for the treatment of digestive tract diseases.Type: GrantFiled: November 7, 1996Date of Patent: May 19, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Ruta Fukutomi, Kohei Inomata, Masashi Suzuki, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Haruko Eguchi
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Patent number: 5736550Abstract: Pyrimidine derivatives useful as a gastrointestinal prokinetic agent, represented by formula ##STR1## wherein X is O or NR.sup.5, Y is O, S or NR.sup.5 wherein R.sup.5 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.1 and R.sup.2 may be the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.3 is CN, or COOR.sup.6 wherein R.sup.6 is a C.sub.1 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 cycloalkyl group, an aryl group or the like;R.sup.4 is --SR.sup.7 or --NR.sup.8 R.sup.9 wherein R.sup.7 is a C.sub.1 -C.sub.6 alkyl group;R.sup.8 is a C.sub.1 -C.sub.6 alkyl group or the like;R.sup.9 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or the like, or R.sup.8 and R.sup.9 may represent, together with the nitrogen atom to which they are attached, an N-substituted piperazine ring of formula (X) ##STR2## wherein R.sup.10 represents a C.sub.1 -C.sub.6 alkyl group or the like or a pharmacologically acceptable salt thereof.Type: GrantFiled: November 15, 1996Date of Patent: April 7, 1998Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Ruta Fukutomi, Kohei Inomata, Masashi Suzuki, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Haruko Eguchi
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Patent number: 5684003Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof are selective agonists for 5-HT.sub.4 receptors. ##STR1## wherein Ak is a C.sub.3 -C.sub.6 alkyl group, and R is a C.sub.2 -C.sub.6 alkyl group, a C.sub.3 -C.sub.6 alkenyl group, a C.sub.3 -C.sub.6 alkynyl group, a C.sub.3 -C.sub.7 cycloalkyl group or a C.sub.3 -C.sub.6 cycloalkylmethyl group.Type: GrantFiled: October 12, 1995Date of Patent: November 4, 1997Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Masashi Suzuki, Ruta Fukutomi, Masahiro Ueno, Koichiro Hagihara, Takeo Arai, Setsuko Mino, Yumiko Noguchi
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Patent number: 5344831Abstract: Diazabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein R is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, oxoalkyl, alkoxycarbonylalkyl, alkoxycarbonyl, acyl, dialkylaminoalkyl, hydroxyalkyl, haloalkyl, cyanoalkyl, heterocycloalkyl, aryl, heteroarylalkyl or arylalkyl, the aryl group and the aryl moiety being optionally substituted by alkoxy, nitro, alkyl, amino or halo;R.sup.2 is hydrogen or alkyl;R.sup.3 and R.sup.4 may be the same or different and each is hydrogen, alkyl, alkenyl, acyl, alkoxyalkyl or arylalkyl wherein the aryl moiety is optionally substituted by alkoxy, nitro, alkyl, amino or halo;with the proviso that when R.sup.2 is hydrogen and both R.sup.3 and R.sup.4 are methyl, R.sup.1 does not represent hydrogen, alkyl, unsubstituted benzyl or dimethylaminoethyl; having 5-HT.sub.3 receptor antagonist activity.Type: GrantFiled: January 28, 1993Date of Patent: September 6, 1994Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Hiroaki Satoh, Haruhiko Kikuchi, Kazuhiko Yamada, Ruta Fukutomi, Masashi Suzuki, Koichiro Hagihara, Toru Hayakawa, Takeo Arai, Setsuko Mino
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Patent number: 5256656Abstract: Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide;X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.Type: GrantFiled: May 12, 1992Date of Patent: October 26, 1993Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Nobuhiro Yahata, Kiochiro Hagihara, Toru Hayakawa, Setsuko Mino, Makoto Yanai
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Patent number: 5246945Abstract: Disclosed are compounds of formula (I) ##STR1## in which A is ##STR2## The compounds are selective antagonists of 5HT at 5-HT.sub.3 receptors and useful in the treatment of psychotic disorders, neurotic diseases, gastric stasis symptoms, gastrointestinal disorders, nausea and vomiting.Type: GrantFiled: February 4, 1992Date of Patent: September 21, 1993Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Toshio Suguro, Koichiro Hagihara, Toru Hayakawa, Setsuko Mino
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Patent number: 5187166Abstract: Azabicyclo derivatives of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein A is a group of formula (a), (b) or (c): ##STR2## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.10 alkyl, aralkyl or di(C.sub.1 -C.sub.4) alkylamino(C.sub.1 -C.sub.6)alkyl;R.sub.2, R.sub.3 and R.sub.4 may be the same or different and each is hydrogen, amino, halogen, C.sub.1 -C.sub.4 alkoxy or phthalimide; X is O or NH;R is C.sub.1 -C.sub.4 alkyl; andY is NR, O or S;having 5-HT.sub.3 receptor antagonist activity.Type: GrantFiled: July 16, 1991Date of Patent: February 16, 1993Assignee: Nisshin Flour Milling Co., Ltd.Inventors: Haruhiko Kikuchi, Hiroaki Satoh, Nobuhiro Yahata, Koichiro Hagihara, Toru Hayakawa, Setsuko Mino, Makoto Yanai