Abstract: The present disclosure can provide a photosensitive resin composition, film, and electronic device having excellent high-resolution patterning at low light intensity, excellent pattern adhesion, fine patterning, and excellent cured film properties.

Abstract: The present invention relates to a novel oligonucleotide primer used for the synthesis of 5?-capped RNA. The novel oligonucleotide primer for RNA capping provided as Formula 1 in the present invention can be usefully utilized in the fields of nucleic acid therapeutic agents or vaccines.

Abstract: The present invention relates to a pyrrolopyridine derivative, a racemate thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and use thereof. The compound of the present invention has high selectivity and bioactivity against human immunodeficiency virus (HIV), and low toxicity, thus being useful as a therapeutic agent for viral infection, particularly human immunodeficiency virus (HIV) infection.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating renal diseases, comprising, as an active ingredient, exosomes isolated from precursor cells of induced pluripotent stem cell-derived mesenchymal stem cells, the precursor cells having been treated or not having been treated with a pretreatment material. Exosomes of the present invention exhibit an effect of preventing or treating renal diseases that is more improved than that of exosomes isolated from conventional mesenchymal stem cells, thereby being effectively usable for relevant research and development and productization.

Abstract: This application relates to a magnetically actuatable functional microscaffold for efficient targeted therapy of intractable diseases and a preparation method thereof. The magnetically actuatable functional microscaffold and the preparation method can enable the application of magnetic nanoparticles according to the status of the scaffold and enable various types of targeted therapy in the field of targeted therapy of intractable diseases.

Abstract: Provided is a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof; a pharmaceutical composition for the prevention or treatment of Sirt6-associated diseases, including as an active ingredient, a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof; and a method for treating Sirt6-associated diseases including administering a phthalazinone compound, or a racemate, steroisomer or pharmaceutically acceptable salt thereof to a subject in need.

Abstract: The present disclosure can provide a photosensitive resin composition, film, and electronic device having excellent high-resolution patterning at low light intensity, excellent pattern adhesion, fine patterning, and excellent cured film properties.

Abstract: Disclosed is a light-emitting diode (LED) lighting apparatus having a multifunctional heat sink flange, which includes an LED board on which a transmitted light cap and a plurality of LEDs are mounted, a main heat sink formed of magnesium or an magnesium alloy, an auxiliary heat sink formed of a conductive/polymeric resin material for heat dissipation, a heat sink upper case formed of a conductive/polymeric resin material for heat dissipation, and a power supply. The main heat sink includes multiple streamlined heat sink segments that are integrally formed on an outer surface thereof so as to radially protrude to allow air to flow in all directions, and a heat sink flange formed along an outer circumference of a bottom thereof such that omega-shaped wings having enclosed holes and inverse omega-shaped open holes are alternately formed.

Abstract: Disclosed herein is an LED-type illuminating module, which independently functions as an illuminating apparatus and which is used to constitute various kinds of illuminating apparatuses having desired outputs by providing a plurality of the LED-type illuminating modules on a module fixing plate 8 of a predetermined area, including: a light transmission or diffusion plate; an LED substrate on which LEDs are fixed at regular intervals by soldering; a radiator formed by die-casting a light metal alloy; a waterproof ring; a plurality of radiating plates made of a light metal alloy; a housing formed by injection-molding a conductive polymer resin material; a waterproof packing; and a power supply converter.

Abstract: Disclosed is a light-emitting diode (LED) lighting apparatus having a multifunctional heat sink flange, which includes an LED board on which a transmitted light cap and a plurality of LEDs are mounted, a main heat sink formed of magnesium or an magnesium alloy, an auxiliary heat sink formed of a conductive/polymeric resin material for heat dissipation, a heat sink upper case formed of a conductive/polymeric resin material for heat dissipation, and a power supply. The main heat sink includes multiple streamlined heat sink segments that are integrally formed on an outer surface thereof so as to radially protrude to allow air to flow in all directions, and a heat sink flange formed along an outer circumference of a bottom thereof such that omega-shaped wings having enclosed holes and inverse omega-shaped open holes are alternately formed.

Abstract: Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.

Abstract: Disclosed is a closed type photo-bio reacting apparatus for microalgae. The apparatus includes a reactor body, a hollow fiber membrane contact unit, a fluid circulating pump, a light source, and an angle adjusting lift. The reactor body cultures the microalgae. The hollow fiber membrane contact unit is disposed in the reactor body and supplies carbon dioxide to culture solution circulating in the reactor body. The fluid circulating pump circulates the culture solution in the reactor body. The light source irradiates light into the reactor body. The angle adjusting lift adjusts an inclination angle of the reactor body according to an irradiation angle of the light source.

Abstract: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner.

Abstract: Disclosed herein is an LED-type illuminating module, which independently functions as an illuminating apparatus and which is used to constitute various kinds of illuminating apparatuses having desired outputs by providing a plurality of the LED-type illuminating modules on a module fixing plate 8 of a predetermined area, including: a light transmission or diffusion plate; an LED substrate on which LEDs are fixed at regular intervals by soldering; a radiator formed by die-casting a light metal alloy; a waterproof ring; a plurality of radiating plates made of a light metal alloy; a housing formed by injection-molding a conductive polymer resin material; a waterproof packing; and a power supply converter.

Abstract: Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases.

Abstract: Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle sensor for measuring protease activity in which a fluorophore- and a quencher-conjugated peptide substrate is conjugated to a biocompatible polymer nanoparticle. The peptide substrate is specifically lysed by a protease. The sensor according to the present invention is capable of inhibiting emission of fluorescence with high extinctive activity of the quencher on a fluorescent material. But strong fluorescence is specifically emitted only if the peptide substrate is lysed by a specific protease. Therefore, the sensor is especially useful as a method for screening a novel drug such as a protease overexpression inhibitor, and early diagnosis of incurable diseases and various diseases such as autoimmune diseases including cancer, osteoarthritis, rheumatoid arthritis and dementia.

Abstract: Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases.

Abstract: Provided is an anticancer prodrug sensitive to a target protease. The anticancer prodrug includes an anticancer drug, peptide that is specifically decomposed by the target protease excessively secreted by cancer cells, and a polymer that is specifically accumulated at a target cancer site. When the inactive anticancer prodrug is administered, the anticancer prodrug is accumulated at the target caner site and then the peptide is decomposed by irradiation of radioactive rays, thereby releasing an active anticancer drug at the target caner site. Accordingly, destruction of normal cells can be minimized and a high anticancer therapeutic effect can be obtained by using a small amount of the anticancer drug administered and a small amount of radioactive rays irradiated.

Abstract: Disclosed are a metal nanoparticle onto which a peptide substrate specifically degraded by protease and fluorophore are chemically modified for selectively imaging protease expressed in cell and in tissue in a human body, and the use thereof. Also, a quantitative analysis method of protease using the metal nanoparticle, a cell imaging method and a drug screening method of inhibiting a protease overexpression are provided. In detail, the present invention is directed to a metal nanoparticle having a peptide substrate and fluorophore coupled thereto, the peptide substrate and the fluorophore being specifically degraded by due to a protease activated in various ways in cell and in a human body to exhibit fluorescence. Hence, the metal nanoparticle can be used to rapidly screen activation and inhibition of the protease in the imaging manner.

Abstract: Compound bow in which a cable interfering with advance of an arrow is removed to improve shooting accuracy of the arrow, to prevent the distortion of the bow, and to simply manipulate equipment of the bow. The compound bow comprises: handle having fixing portions protruding from one surface thereof; wing units coupled to both ends of the handle; rotating units rotatably coupled to free ends of the wing units, respectively, by an eccentric shaft; a bow string connected between the respective rotating units; a pulley shaft-coupled to the fixing portion of the handle; cable members each having one end connected to each rotating unit and the other end connected to the free end of each wing unit via the pulley. Optionally tensioner member may be installed on one side of each cable member and ratchet member may be installed on the respective rotating units and wing units.