Abstract: Provided is a composition for reforming skin microbiota comprising a ginseng extract; a ginseng-derived antibacterial agent; and alkanediol, to increase the fraction of beneficial bacteria in skin microbiota by promoting the growth of beneficial bacteria and inhibiting the growth of harmful bacteria, whereby the constitution of skin microbiota is reformed and maintained in a balanced state, ultimately helping improve human skin health.

Abstract: The present invention relates to process of purifying the angiogensis inhibitor proteins expressed in E. coli and to the use of recombinant kringle 1-3 (; greenstatin) purified by the above process as a angiogenesis inhibitor and an anticancer agent. Particularly, according to the process of purifying the protein, the angiogenesis inhibitor proteins overexpressed are solubilized, refolded, and purified as a pure and active form. The greenstatin purified by the process specifically suppresses endothelial cell proliferation, anaiogenesis, and the growth of lung cancer, skin cancer, and brain tumor. Therefore, the process of this invention is applicable to the mass-production of angiogenesis inhibitor proteins such as greenstatin which is useful for the treatment of glaucoma, retinopathy, and cancers.