Abstract: The present disclosure provides methods and reagents useful for analyzing protein-protein interfaces such as interfaces between a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein. In some embodiments, the target and/or presenter proteins are intracellular proteins. In some embodiments, the target and/or presenter proteins are mammalian proteins.

Abstract: Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof, a pharmaceutical composition comprising a compound of the present disclosure, together with a pharmaceutically acceptable excipient thereof, and a method of treating cancer with the same.

Abstract: System for establishing a surface shape. The system includes a compliant substrate including the surface and having a reverse side, and a plurality of discrete actuators engaging the reverse side and arranged in a selected pattern to control the surface shape as individual discrete activators are activated. It is preferred that the actuators have multiple discrete stable states of elongation. A particularly preferred embodiment uses actuators that are binary with two stable states of elongation.

Abstract: System for establishing a surface shape. The system includes a compliant substrate including the surface and having a reverse side, and a plurality of discrete actuators engaging the reverse side and arranged in a selected pattern to control the surface shape as individual discrete activators are activated. It is preferred that the actuators have multiple discrete stable states of elongation. A particularly preferred embodiment uses actuators that are binary with two stable states of elongation.

Abstract: An extracellular leucine aminopeptidase was isolated from the culture medium of Streptomyces therrnonitrificans which is a Zn.sup.2+ -dependent metalloenzyme which comprises an amino acid sequence Lys-Phe-Ser-Lys-Lys-Phe-Asn-Glu (SEQ ID NO: 3) at the N-terminal thereof, and amino acid sequences of Glu-Pro-Gly-Thr-Gly-Ala-Leu-Glu-Pro (SEQ ID NO: 4) and Asn-Pro-Asp-Ile-Val-Tyr (SEQ ID NO: 5) at other regions thereof. The aminopeptidase has a pH optimum of 7.5 to 9.0, a temperature optimum of 30.degree. to 50.degree. C., and an apparent molecular weight as determined by sodium dodecyl sulfate polyacrylamide gel electrophoresis under reducing conditions of 41 to 45 kDa, and as determined by gel filtration under native state conditions of 36 to 40 kDa.

Abstract: A temperature monitoring system comprises a sensor for measuring the surrounding temperature, a timer for generating clock data, a controller for reading temperatures at predetermined intervals and storing selected temperature data and corresponding time data in memory, input switches for entering commands and data, a data display, and first and second alarm indicators. The controller operates in predetermined steps to activate the first alarm to indicate a current alarm condition and to activate the second alarm to indicate a past alarm condition. The controller selectively switches the display between normal and alarm modes to show differing time and temperature data depending on the temperature conditions monitored. The user may review alarm histories, including total alarm time and, for each past alarm period, maximum temperature, starting time and alarm duration, which have been calculated and stored.

Abstract: Method of fabricating a direct-heated cathode structure comprising prepunching process wherein fixing segments are inserted to slot in the ceramic base and bended about 45, and finish punching process wherein upper end of prepunched fixing segments are pressed over the ceramic base. Direct-heated cathode structure comprising supporting bars with a supporting protuberance at their upper end and a barricade at their middle to prevent deformation during welding of springs and to confine affection of buckling during electric resistance welding of conductive tape respectively.

Abstract: A process for producing blackboard crayon by molding a mixture of calcium carbonate, titanium oxide and zinc oxide in place of conventional calcined gypsum or chalk, a resinous material primarily containing paraffin, beef tallow or palm oil as a coagulant, and a solvent, into a stick form. The blackboard crayon does not scatter dust.