Abstract: The present invention discloses a matching system between a convective cell in a weather radar image and lightning, and a control method thereof. In other words, according to the invention, convective cells are detected in a weather radar image, lightning is detected through a total lightning detection system, and the detected lightning is matched with the detected convective cells in the weather radar image. Therefore, it is possible to rapidly and accurately match and confirm a lightning-generated convective cell of a plurality of convective cells.

Abstract: A method for preparing a radiopharmaceutical and, specifically, a method for preparing an organic fluoride-aliphatic compound usable as a radiopharmaceutical, a method for purifying the prepared organic fluoride-aliphatic compound, and a method for preparing a radiopharmaceutical by using a cassette comprising a backdraft preventing reaction container. A method for preparing an organic fluorinated aliphatic compound includes allowing a fluorine salt to react with a leaving group-containing aliphatic compound by using a multifunctional solvent represented by the following Chemical Formula 1 to obtain an aliphatic compound labeled with [18F] fluoride substituting for the leaving group. The organic fluoride-aliphatic compound can be prepared and purified through even a simple process at high yield, high efficiency, and high purity, and the radiopharmaceutical can be safely prepared without damage to a synthetic apparatus.

Abstract: The present invention discloses a system for predicting a path of a connective cell and a control method thereof. According to the invention, a connective cell is detected in a weather radar image, and a path of the detected convective cell is predicted on the basis of a plurality of information stored in advance, thereby guiding various kinds of information about the connective cell including lightning in advance.

Abstract: The present invention discloses a matching system between a convective cell in a weather radar image and lightning, and a control method thereof. In other words, according to the invention, convective cells are detected in a weather radar image, lightning is detected through a total lightning detection system, and the detected lightning is matched with the detected convective cells in the weather radar image. Therefore, it is possible to rapidly and accurately match and confirm a lightning-generated convective cell of a plurality of convective cells.

Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.

Abstract: The present invention relates to a method for labelling fluorine-18, which is a radioisotope, and more specifically, to a method for labelling a [18F]fluoride in a method for preparing an organic [18F]fluoro compound by reacting an alkyl halide or an alkyl sulfonate with a [18F]fluoride, wherein a [18F]fluoride supported on a quaternary alkyl ammonium polymer support is eluted using a solution containing a metal salt or a quaternary ammonium salt with an adjusted pH, and a base is not additionally used. The present invention enables a labeling reaction without an additional base after precisely reflecting the concentration of a base absolutely necessary for the nucleophilic substitution of a [18F]fluoride or eluting a [18F]fluoride using a [18F]fluoride eluent with an adjusted pH, thereby stably obtaining a [18F]fluoride-labelled compound in a high yield, and is thus useful for production of fluorine-18-labelled radioactive medical supplies.

Abstract: A method of providing a membership service by a membership service providing server connected with a user terminal, wherein the method includes: a) receiving a membership service subscription request; b) receiving representative card information; c) receiving affiliated company selection information about an affiliated company; d) matching and storing the user information, the affiliated company selection information, and the representative card information; and e) providing the user terminal with at least one of mileage, a stamp, and a coupon provided by the affiliated company when receiving a membership service request through the representative card from an affiliated company server corresponding to the affiliated company selection information.

Abstract: A membership service providing server is connected with a user terminal and includes: a) receiving a membership service subscription request; b) receiving representative card information about a representative card used for the membership service from the user terminal and registering the representative card information; c) receiving affiliated company selection information about an affiliated company; d) matching and storing the user information, the affiliated company selection information, and the representative card information; and e) providing the user terminal with at least one of mileage, a stamp, and a coupon provided by the affiliated company when receiving a membership service request through the representative card from an affiliated company server corresponding to the affiliated company selection information.

Abstract: This invention relates to methods, which provide access to [F-18]fluoropegylated (aryl/heteraryl vinyl)-phenyl methyl amine derivatives.

Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.

Abstract: The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM, which has increased lipophilicity, of a vector in a nucleophilic reaction which offers a convenient and time-saving way to purify the product from non-reacted precursors vector-LM and by-products LM.

Abstract: The present invention relates to (3-fluoro-2-hydroxy)propyl-functionalized aryl derivatives or to the pharmaceutically acceptable salt thereof, to a method for preparing same, and to a pharmaceutical composition containing same as active ingredients for the diagnosis or treatment of neurodegenerative brain diseases. The aryl derivatives of the present invention are (3-fluoro-2-hydroxy)propyl-functionalized to increase the polarity thereof, and therefore the drugs containing the aryl derivatives can easily permeate into the cerebrovascular membrane, thus increasing the effectiveness of the drugs. As the aryl derivatives of the present invention strongly bind to ?-amyloid, the aryl derivatives, when labeled with radioisotope, can be used as a diagnostic agent for non-invasively diagnosing early Alzheimer's disease.

Abstract: The present invention provides novel and advantageous processes for preparing and purifying chemical compounds such as pharmaceuticals. The processes comprise a nucleophilic substitution reaction with a moiety X wherein the leaving group L of a substrate S in the reaction is covalently attached to a purification moiety M. This concept offers a convenient and lime-saving way to purity the desired product S-X from non-reacted precursors S-L-M and by-products L-M.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of primary or secondary organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with primary or secondary alkyl halide or primary or secondary alkyl sulfonate in the presence of alcohol of Chemical Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: 2-arylbenzothiophene derivatives or pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition for the diagnosis or treatment of degenerative brain disease containing the same as an active ingredient. Since the 2-arylbenzothiophene derivatives of Formula 1 have a relatively high binding affinity for ?-amyloid, they can be used as diagnostic reagents for diagnosing Alzheimer's disease at an early stage by non-invasive techniques when they are labeled with radioisotopes: wherein R1-R4, V, W, X, Y and Z are as defined in the Detailed Descript of the specification. Further, when the pharmaceutical composition containing the 2-arylbenzothiophene derivative binds with a low-molecular weight ?-amyloid peptide binding compound, generation of malignant high-molecular weight ?-amyloid deposits is minimized. Accordingly, the pharmaceutical composition can be used as a therapeutic agent of degenerative brain disease such as Alzheimer's disease.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [18F]florbetaben or [18F]AV-45 having <Chemistry Formula 11> and <Chemistry Formula 12>, respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

Abstract: A half ball valve includes a body including cavity having an assembly opening, a stem opening formed at a side of the body opposite to the assembly opening to connect the cavity and the outside, and a first connection hole inclined with respect to an axis of the stem opening. A ball is accommodated in the cavity of the body through the assembly opening to be capable of rotating to switch between an open position at which the first connection hole is open and a close position at which the first connection hole is blocked. A passage is formed in the ball inclined with respect to an axis of the stem opening and is connected to the first connection hole at the open position. A stem connects a control lever outside the body and the ball along the stem opening. A body cap having a second connection hole connected to the passage of the ball is coupled to the body to cover the cavity at the assembly opening side. A packing is interposed between an outer surface of the ball and an inner wall of the body.

Abstract: A half ball valve includes a body including cavity having an assembly opening, a stem opening formed at a side of the body opposite to the assembly opening to connect the cavity and the outside, and a first connection hole inclined with respect to an axis of the stem opening. A ball is accommodated in the cavity of the body through the assembly opening to be capable of rotating to switch between an open position at which the first connection hole is open and a close position at which the first connection hole is blocked. A passage is formed in the ball inclined with respect to an axis of the stem opening and is connected to the first connection hole at the open position. A stem connects a control lever outside the body and the ball along the stem opening. A body cap having a second connection hole connected to the passage of the ball is coupled to the body to cover the cavity at the assembly opening side. A packing is interposed between an outer surface of the ball and an inner wall of the body.