Abstract: A computer system can include an input device having a housing defining an internal volume. The housing can include a grip portion and a base portion defining an aperture. The computer system can also include a tilt sensor disposed in the internal volume, a position sensor disposed at the aperture, and a processor. The processor can be electrically coupled to the position sensor, the tilt sensor, and a memory component storing electronic instructions that, when executed by the processor, cause the processor to receive a first input from the tilt sensor, receive a second input from the position sensor, determine, based on the first and second inputs, if the base is in contact with a support surface and an angle of the base relative to the support surface. The processor can also output a signal based on the angle if the base is in contact with the support surface.

Abstract: A three-dimensional control system includes an input device, a computing device, and a tracking assembly. The input device can include an input sensor, an inertial measurement unit sensor, and an ultrasonic speaker. The tracking assembly can include a plurality of ultrasonic microphones and an inertial measurement unit disposed on or with the computing device. The plurality of ultrasonic microphones can include three microphones in a first plane and at least one other ultrasonic microphone disposed out of the first plane. The ultrasonic microphones can be configured to detect ultrasonic waves output by the speaker of the input device and the computing device can triangulate the position of the input device relative to the computing device in space.

Abstract: A computer input system includes a mouse including a housing having an interior surface defining an internal volume and a sensor assembly disposed in the internal volume. A processor is electrically coupled to the sensor assembly and a memory component having electronic instructions stored thereon that, when executed by the processor, causes the processor to determine an orientation of the mouse relative to a hand based on a touch input from the hand detected by the sensor assembly. The mouse can also have a circular array of touch sensors or lights that detect hand position and provide orientation information to the user.

Abstract: An input device, such as a mouse, can include a housing defining an exterior grip portion and an internal volume, a sensor assembly disposed in the internal volume, and an emitter electrically coupled to the sensor assembly. In response to the sensor assembly detecting a first touch input on the housing, the emitter sends a first signal including information regarding an angular position of the grip portion. In response to the sensor assembly detecting a second touch input on the housing, the emitter sends a second signal including information regarding a direction of a force exerted on the housing from the second touch input.

Abstract: An input device can include a housing defining an internal volume and a lower portion, the lower portion defining an aperture, an input sensor disposed in the internal volume, and a haptic assembly disposed in the internal volume. The haptic assembly can include an actuator and a foot coupled to the actuator and aligned with the aperture. The actuator can be configured to selectively extend the foot through the aperture to vary a sliding resistance of the input device on a support surface.

Abstract: The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are provided for treating an individual in need thereof (e.g., an individual who is obese and/or has diabetes) by administering an anti-NMU/NMUR agent (e.g., an anti-NMU antibody). For example, methods and compositions are provided for increasing circulating insulin in an individual. Methods and compositions are also provided for detecting neuromedin U (NMU) (e.g., in a biological sample such as serum). Methods and compositions are also provided for predicting whether an individual will develop diabetes and/or PDAC, and for identifying an individual who would benefit from administration of an anti-NMU/NMUR agent.

Abstract: The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are provided for treating an individual in need thereof (e.g., an individual who is obese and/or has diabetes) by administering an anti-NMU/NMUR agent (e.g., an anti-NMU antibody). For example, methods and compositions are provided for increasing circulating insulin in an individual. Methods and compositions are also provided for detecting neuromedin U (NMU) (e.g., in a biological sample such as serum). Methods and compositions are also provided for predicting whether an individual will develop diabetes and/or PDAC, and for identifying an individual who would benefit from administration of an anti-NMU/NMUR agent.

Abstract: The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are provided for treating an individual in need thereof (e.g., an individual who is obese and/or has diabetes) by administering an anti-NMU/NMUR agent (e.g., an anti-NMU antibody). For example, methods and compositions are provided for increasing circulating insulin in an individual. Methods and compositions are also provided for detecting neuromedin U (NMU) (e.g., in a biological sample such as serum). Methods and compositions are also provided for predicting whether an individual will develop diabetes and/or PDAC, and for identifying an individual who would benefit from administration of an anti-NMU/NMUR agent.

Abstract: Regulatory T cells (Treg) are engineered to express a chimeric antigen receptor (CAR), that specifically binds to a non-endogenous antigenic moiety; and are administered in combination with an effective dose of targeting antibodies, which antibodies (i) bind to an antigen localized at a site of inflammation and (ii) are labeled with the antigenic moiety, wherein inflammation is decreased at the targeted site.

Abstract: The inventors have produced two high specificity and high affinity monoclonal antibodies that bind to human neuromedin U (NMU). Methods and compositions are provided for treating an individual in need thereof (e.g., an individual who is obese and/or has diabetes) by administering an anti-NMU/NMUR agent (e.g., an anti-NMU antibody). For example, methods and compositions are provided for increasing circulating insulin in an individual. Methods and compositions are also provided for detecting neuromedin U (NMU) (e.g., in a biological sample such as serum). Methods and compositions are also provided for predicting whether an individual will develop diabetes and/or PDAC, and for identifying an individual who would benefit from administration of an anti-NMU/NMUR agent.

Abstract: Methods and compositions are provided for modulating pancreatic islet ? cell proliferation. Aspects of the methods include promoting ? cell proliferation by providing agents that promote PDGFR signaling, or inhibiting ? cell proliferation by providing agents that inhibit PDGFR signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. Also provided are reagents and kits thereof that find use in practicing the subject methods.

Abstract: Methods and compositions are provided for modulating pancreatic islet ?-cell development. Aspects of the methods include promoting ?-cell development by providing agents that promote calcineurin/N FAT signaling, and inhibiting ?-cell development by providing agents that inhibit calcineurin/NFAT signaling. These methods find a number of uses, including, for example, in the treatment of diabetes and human islet diseases. In addition, reagents, devices and kits thereof that find use in practicing the subject methods are provided.

Abstract: A circuit is disclosed for switching power to a battery operated device, particularly a portable radio transceiver. The power control circuit uses an on/off switch that remains in a fixed "on" or "off" position instead of using a momentary push button switch. The circuit allows powering down the radio to prevent deep discharging of the battery even though the switch remains in the "on" position. Also, the circuit allows the radio to continue to be powered up under microprocessor control after the switch is placed in the "off" position.

Abstract: A select key is pivotable in a forward direction and a reverse direction to at least a step position and a fast position. In the fast position, the device functions are scrolled rapidly, and in the step position, the device functions are stepwise scrolled. A select key is centrally disposed on a rocking lever, enabling simple and efficient one-hand operation.

Abstract: A combination antenna and microphone extension assembly is rotatably mounted on a portable communication unit to enable deployment from a stored position alongside the housing of the unit to an extended operating position with the antenna deployed and a speaking region connected through an acoutstic cavity in the assembly to the microphone on the unit providing extended spacing between the speaker on the housing and the speaking region to span the distance between the mouth and ears of the user.

Abstract: A composition for an intergranular insulation type semiconductive ceramic capacitor essentially consisting of 1 mole of SrTiO.sub.3, 0.005 mole to 0.012 mole of TiO.sub.2, and 0.003 mole to 0.006 mole of a quinquevalent ion oxide selected from a group consisting of Nb.sub.2 O.sub.5, Ta.sub.2 O.sub.5, Sb.sub.2 O.sub.5 and the mixture thereof. An intergranular insulation type semiconductive ceramic capacitor is made by sintering a ceramic body made of the composition at a temperature of not less than 1,500.degree. C. in the atmosphere, to form a sintered body having a liquid phase at its grain boundaries, and cooling the sintered body so that the liquid phase forms an intergranular insulating layer. The intergranular insulation type semiconductive ceramic capacitor exhibits a dielectric constant of not less than 40,000 and an insulation resistance of not less than 10.sup.9 .OMEGA..

Abstract: Apparatus for measuring a physical quantity such as pressure, temperature, strain etc., by using a beat frequency of a longitudinal mode, a transverse mode or two polarization modes of the optical fiber laser. In the rare-earth optical fiber laser as a resonator, there are two different polarization modes normal to each other. Since the optical path lengths of the optical fiber laser for the two polarization modes are different, longitudinal mode frequencies of each polarization mode are different depending on the birefringence of resonator which is varied as an external physical quantity such as pressure, temperature, strain etc. Due to the variation in the birefringence of the resonator, the longitudinal mode frequency difference between two polarization modes becomes varied. This variation is linearly proportional to the physical quantity externally applied. The difference in longitudinal mode frequency between polarization modes can be measured from a beat signal of the polarization modes.

Abstract: A caption VCR having a caption decoder, therein, for detecting a caption signal from a broadcasting signal or detecting a caption signal recorded on a VCR tape. The caption VCR normally operates to display a video signal having no caption signal. However, if the caption signal including character and screen data is detected by the caption decoder, the caption VCR displays the caption signal including the character and screen data. Also, a method of displaying the caption signal from the caption decoder together with an audio signal and a video signal in the caption VCR is provided. Therefore, it is convenient for the deaf person or foreign language learner to watch a desired image containing the caption signal on the screen utilizing the caption decoder.

Abstract: A magnetic field sensing and canceling circuit for use with a cathode ray tube (CRT) has a closed loop system consisting of flux gate sensors to measure external magnetic fields and magnetic field cancellation coils around the perimeter of the faceplate of the CRT to cancel the fields and thus minimize color and positional ac image distortion. The coils are mounted on an enclosure fabricated of a high permeability material and are positioned around the perimeter of the CRT's faceplate. Four of the coils are parallel to the top, bottom, and sides of the enclosure opening and a fifth coil is wound around the enclosure adjacent the CRT faceplate. The magnetic flux gate sensors provide output signals that are functions of the detected fields. These signals control the current in the magetic field cancellation coils and thus control the cancellation fields.

Abstract: The present invention relates to a novel process for the preparation of insecticidally active esters of the general formula (I) ##STR1## wherein R.sub.1 and R.sub.2 are the same or diferent from each other and represent a hydrogen or a halogen atom; R.sub.3 represents ##STR2## (wherein R.sub.4 and R.sub.5 represent a chlorine or bromine atom or a methyl group when R.sub.4 is identical to R.sub.5, but R.sub.4 represents a chlorine or bromine atom or a methyl group and R.sub.5 represents a trifluoromethyl group when R.sub.4 is different from R.sub.5, and R.sub.6 represents a halogen atom or a difluoromethoxy group); and R.sub.8 represents a hydrogen or a cyano group.The characteristic of the present invention is a one-step procedure comprising directly condensing an organic acid, an aldehyde (and a water-soluble cyanide) in the presence of a phase transfer catalyst and a water-soluble inorganic base by the use of a sulphonyl compound as a condensing reagent.