Abstract: The present disclosure relates to a biomarker for predicting the sensitivity to a protein kinase inhibitor and a use thereof. The present disclosure provides a marker, a composition, and a kit for predicting the sensitivity to a protein kinase inhibitor, and a prediction method thereof. According to the present disclosure, the marker has an excellent effect of predicting the sensitivity to a protein kinase inhibitor, and thus the present disclosure can be useful for cancer treatment.

Abstract: A trigger circuit includes an off-time controller configured to receive a sensing voltage by sensing a driving current and to compare the sensing voltage to first and second certain voltages that are close to a zero voltage value and symmetrical to the zero voltage value to control a turn-off time of a driving switch in order for the sensing voltage to correspond to the zero voltage value at the turn-on time point of the driving switch and a switching controller configured to provide a switching control signal for turning on the driving switch at the turn-on time point of the driving switch.

Abstract: A Pulse-Width Modulation (PWM) controlling apparatus includes a valley detector configured to detect a valley of an auxiliary winding voltage of a flyback converter, an output voltage controller configured to output a first PWM control signal by performing averaging and sampling of the auxiliary winding voltage, an output current controller configured to output a second PWM control signal by performing an average current mode method on a current signal (CS) voltage, a latch configured to output a gate control signal after being supplied with the result of a logical OR operation of the first PWM control signal output by the output voltage controller and the second PWM control signal output by the output current controller, or an output signal of the valley detector, and a gate controller configured to perform a turning-on or turning-off operation of a first switch based on the gate control signal.

Abstract: The present invention relates to a novel biomarker for predicting susceptibility to an MET inhibitor, and a use thereof, and more specifically, the present invention provides: a biomarker for predicting susceptibility to the MET inhibitor, the biomarker comprising the Immunoglobulin Superfamily member 1 (IGSF1, NM_001555.

Abstract: A current compensation circuit includes a current compensator configured to measure a compensation time in which a sensing voltage generated by a driving current passing through a driving switching element drops below a first certain voltage in response to the driving switching element being turned on and configured to delay a turn-off point of the driving switching element from a point in which the sensing voltage reaches a second certain voltage during the measured compensation time and a switching controller configured to provide a switching control signal at a turn-off point of the delayed driving switching element. Such a current compensation circuit accurately controls an average driving current regardless of change of an input voltage and an output voltage and is able to use a peak current mode control method to operate a light emitting diode.

Abstract: A ballast type detecting circuit includes a ballast signal clamping circuit coupled to a ballast, wherein the ballast signal clamping unit is configured to clamp an output of the ballast, and a ballast type detection circuit configured to compare first and second reference clocks and the clamped output of the ballast to determine a type of the ballast, each of the first and second reference clocks having a frequency lower than an output frequency of a first type ballast and higher than an output frequency of a second type ballast. Thus, the ballast type detecting circuit detects a type of electronic ballast and magnetic ballast based on a digital output signal and decreases a number of outside circuit elements through a ballast type detection based on a digital output signal.

Abstract: The present invention relates to a composition for treatment or metastasis suppression of cancers which includes a p34 expression inhibitor or activity inhibitor as an active ingredient. According to the present invention, the p34 protein knock-down causes monoubiquitination of PTEN and accordingly nuclear localization of PTEN is induced, as a result, an Akt pathway which is related to survival, proliferation, invasive properties and metastatic properties of tumors is inhibited, and thus there is an effect of significantly reducing clonogenic potential and tumor forming potential of various cancer cells which simultaneously express PTEN and NEDD4-1. Consequently, the p34 gene expression inhibitor or p34 protein activity inhibitor according to the present invention can be effectively used as a treatment agent or a metastasis suppression agent for cancers.

Abstract: There are provided a method, a system, and a computer-readable recording medium for processing network traffic. A method for processing network traffic using a switching application specific integrated circuit (ASIC) includes generating, by a software forwarder operated in a software-based network operating system, a message including network processing information, transmitting the message to a switch manager operated in a hardware-based network operating system, learning, by the switch manager, the network processing information, and controlling the switching ASIC with reference to the learned information.

Abstract: Provided are methods of ensuring network continuity performed at a local gateway, a fixed gateway, and a network device. The method of ensuring network continuity performed at a local gateway includes establishing a tunnel with a fixed gateway serving as a relay between an Internet service server and the local gateway, and performing communication with the fixed gateway through the tunnel. Therefore, even when the type of an uplink signal received by a local gateway changes or the local gateway is in an uplink signal shadow area, a terminal connected to the local gateway can be provided with a seamless Internet service.

Abstract: A system including software enables the running software to he upgraded without stopping any service. A system including software includes a task block loaded into a memory the task block being communicable with the outside through a message, and a dynamic module block loaded into the memory, the dynamic module block being symbolically linked with the task block to provide a service corresponding to the message.

Abstract: A switching control circuit includes a switching trigger unit that receives a sensing voltage, which senses a driving current that includes a first and second driving current sections, and that provides a first switching trigger signal based on the sensing voltage in the second current section, an off-time control unit configured to provide a second switching trigger signal in the first driving current section to control a maximum off-time of a driving switching element and a switching control unit configured to turn on the driving switching element based on the first or second switching trigger signal.

Abstract: A trigger circuit includes an off-time controller configured to receive a sensing voltage by sensing a driving current and to compare the sensing voltage to first and second certain voltages that are close to a zero voltage value and symmetrical to the zero voltage value to control a turn-off time of a driving switch in order for the sensing voltage to correspond to the zero voltage value at the turn-on time point of the driving switch and a switching controller configured to provide a switching control signal for turning on the driving switch at the turn-on time point of the driving switch.

Abstract: A trigger circuit includes a high voltage protector configured to scale down a first voltage according to an internal voltage to output a second voltage having a lower level than the first voltage, a switching trigger configured to detect that the outputted second voltage falls below a certain voltage level to provide a switching trigger signal, and a switching controller configured to provide a switching control signal for turning on a driving switching element based on the switching trigger signal.

Abstract: A switching control circuit includes a switching trigger unit that receives a sensing voltage, which senses a driving current that includes a first and second driving current sections, and that provides a first switching trigger signal based on the sensing voltage in the second current section, an off-time control unit configured to provide a second switching trigger signal in the first driving current section to control a maximum off-time of a driving switching element and a switching control unit configured to turn on the driving switching element based on the first or second switching trigger signal.

Abstract: A Pulse-Width Modulation (PWM) controlling apparatus includes a valley detector configured to detect a valley of an auxiliary winding voltage of a flyback converter, an output voltage controller configured to output a first PWM control signal by performing averaging and sampling of the auxiliary winding voltage, an output current controller configured to output a second PWM control signal by performing an average current mode method on a current signal (CS) voltage, a latch configured to output a gate control signal after being supplied with the result of a logical OR operation of the first PWM control signal output by the output voltage controller and the second PWM control signal output by the output current controller, or an output signal of the valley detector, and a gate controller configured to perform a turning-on or turning-off operation of a first switch based on the gate control signal.

Abstract: A trigger circuit includes a high voltage protector configured to scale down a first voltage according to an internal voltage to output a second voltage having a lower level than the first voltage, a switching trigger configured to detect that the outputted second voltage falls below a certain voltage level to provide a switching trigger signal, and a switching controller configured to provide a switching control signal for turning on a driving switching element based on the switching trigger signal.

Abstract: A current compensation circuit includes a current compensator configured to measure a compensation time in which a sensing voltage generated by a driving current passing through a driving switching element drops below a first certain voltage in response to the driving switching element being turned on and configured to delay a turn-off point of the driving switching element from a point in which the sensing voltage reaches a second certain voltage during the measured compensation time and a switching controller configured to provide a switching control signal at a turn-off point of the delayed driving switching element. Such a current compensation circuit accurately controls an average driving current regardless of change of an input voltage and an output voltage and is able to use a peak current mode control method to operate a light emitting diode.

Abstract: The present disclosure relates to a circuit compensation circuit includes a current compensator configured to perform a charging or a discharging of a capacitive element according to whether a sensing voltage is less than or greater than a certain voltage and to delay a turn-off point of a driving switching element until a corresponding discharging quantity is identical to a corresponding charging quantity and a switching controller configured to provide a switching control signal at the delayed turn-off point of the driving switching element.

Abstract: The present disclosure relates to a circuit compensation circuit includes a current compensator configured to perform a charging or a discharging of a capacitive element according to whether a sensing voltage is less than or greater than a certain voltage and to delay a turn-off point of a driving switching element until a corresponding discharging quantity is identical to a corresponding charging quantity and a switching controller configured to provide a switching control signal at the delayed turn-off point of the driving switching element. The present disclosure also relates to a light emitting diode apparatus that includes such a current compensation circuit, and a related method of driving such a current compensation circuit.

Abstract: A ballast type detecting circuit includes a ballast signal clamping circuit coupled to a ballast, wherein the ballast signal clamping unit is configured to clamp an output of the ballast, and a ballast type detection circuit configured to compare first and second reference clocks and the clamped output of the ballast to determine a type of the ballast, each of the first and second reference clocks having a frequency lower than an output frequency of a first type ballast and higher than an output frequency of a second type ballast. Thus, the ballast type detecting circuit detects a type of electronic ballast and magnetic ballast based on a digital output signal and decreases a number of outside circuit elements through a ballast type detection based on a digital output signal.