Patents by Inventor Seungkwon You

Seungkwon You has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising Oct4 in combination with Bmi1 or its upstream regulator, and method for generating induced pluripotent stem cells using the same
    Patent number: 8772031
    Abstract: Disclosed is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule coding for Bmi1; and b) an Oct4 protein or a nucleic acid molecule coding for Oct4. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the genetic factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: July 8, 2014
    Assignee: Korea University Research and Business Foundation
    Inventors: Seungkwon You, Jai-Hee Moon, Jun Sung Kim, Byung Sun Yoon, Jung Han Lee, Eun Kyoung Jun, June Seok Heo
  • Composition for improving skin conditions using fetal mesenchymal stem cells from amniotic fluid
    Patent number: 8586540
    Abstract: The present invention relates to a culture medium for the fetus-derived mesenchymal stem cells in amniotic fluid. More particularly, the present invention relates to a composition for improving skin conditions, comprising the culture medium of fetus-derived mesenchymal stem cells in amniotic fluid as an active ingredient, in which the skin conditions to be improved include whitening, wrinkles, skin damages caused by UV rays or skin lifting. Further, the present invention relates to a method for preparing the composition, comprising the steps of culturing the fetus-derived mesenchymal stem cells in amniotic fluid; and collecting the culture medium.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: November 19, 2013
    Assignee: Stemmedience Co., Ltd.
    Inventors: Seungkwon You, Byung Sun Yoon, Jai-Hee Moon, Eun Kyoung Jun, Jonggun Kim, Hye-Youn Jung, Jung Han Lee, Eulsoon Park, Isaac Maeng, Jun Sung Kim, Jang Ho Lee, Hwang Heui Lee, Jong Won Lee, Kyoung Shik Cho
  • COMPOSITION FOR REPROGRAMMING SOMATIC CELLS TO GENERATE INDUCED PLURIPOTENT STEM CELLS, COMPRISING Oct4 IN COMBINATION WITH Bmi1 OR ITS UPSTREAM REGULATOR, AND METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS USING THE SAME
    Publication number: 20130280808
    Abstract: Disclosed is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule coding for Bmi1; and b) an Oct4 protein or a nucleic acid molecule coding for Oct4. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the genetic factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
    Type: Application
    Filed: May 9, 2013
    Publication date: October 24, 2013
    Inventors: Seungkwon You, Jai-Hee Moon, Jun Sung Kim, Byung Sun Yoon, Jung Han Lee, Eun Kyoung Jun, June Seok Heo
  • Composition for reprogramming somatic cells to generate induced pluripotent stem cells, comprising Bmi1 and low molecular weight substance, and method for generating induced pluripotent stem cells using the same
    Patent number: 8518700
    Abstract: Provided is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule encoding the Bmi1 protein; and b) at least one low molecular weight substance selected from the group consisting of a set of a MEK/ERK (mitogen-activated protein kinase/extracellular regulated kinase) inhibitor and a GSK (glycogen synthase kinase) inhibitor, a set of a G9a HMTase (G9a histone methyltransferase) inhibitor and a DMNT (DNA methyltransferase) inhibitor, and a histone deacetylase inhibitor. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the reprogramming factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: August 27, 2013
    Assignee: Korea University Research and Business Foundation
    Inventors: Seungkwon You, Jai-Hee Moon, Jun Sung Kim, Byung Sun Yoon, Jung Han Lee, Eun Kyoung Jun, June Seok Heo, Ji Hyun Kim, Ji Hye Hwang, Su Hyun Gwon
  • Composition for Improving Skin Conditions Using Fetal Mesenchymal Stem Cells from Amniotic Fluid
    Publication number: 20120141399
    Abstract: The present invention relates to a culture medium for the fetus-derived mesenchymal stem cells in amniotic fluid. More particularly, the present invention relates to a composition for improving skin conditions, comprising the culture medium of fetus-derived mesenchymal stem cells in amniotic fluid as an active ingredient, in which the skin conditions to be improved include whitening, wrinkles, skin damages caused by UV rays or skin lifting. Further, the present invention relates to a method for preparing the composition, comprising the steps of culturing the fetus-derived mesenchymal stem cells in amniotic fluid; and collecting the culture medium.
    Type: Application
    Filed: March 19, 2010
    Publication date: June 7, 2012
    Applicant: STEMMEDIENCE CO., LTD
    Inventors: Seungkwon You, Byung Sun Yoon, Jai-Hee Moon, Eun Kyoung Jun, Jonggun Kim, Hye-Youn Jung, Jung Han Lee, Eulsoon Park, Isaac Maeng, Jun Sung Kim, Jang Ho Lee, Hwang Heui Lee, Jong Won Lee, Kyoung Shik Cho
  • COMPOSITION FOR REPROGRAMMING SOMATIC CELLS TO GENERATE INDUCED PLURIPOTENT STEM CELLS, COMPRISING Bmi1 AND LOW MOLECULAR WEIGHT SUBSTANCE, AND METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS USING THE SAME
    Publication number: 20110275157
    Abstract: Provided is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule encoding the Bmi1 protein; and b) at least one low molecular weight substance selected from the group consisting of a set of a MEK/ERK (mitogen-activated protein kinase/extracellular regulated kinase) inhibitor and a GSK (glycogen synthase kinase) inhibitor, a set of a G9a HMTase (G9a histone methyltransferase) inhibitor and a DMNT (DNA methyltransferase) inhibitor, and a histone deacetylase inhibitor. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the reprogramming factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
    Type: Application
    Filed: May 9, 2011
    Publication date: November 10, 2011
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Seungkwon YOU, Jai-Hee MOON, Jun Sung KIM, Byung Sun YOON, Jung Han LEE, Eun Kyoung JUN, June Seok HEO, Ji Hyun KIM, Ji Hye HWANG, Su Hyun GWON
  • COMPOSITION FOR REPROGRAMMING SOMATIC CELLS TO GENERATE INDUCED PLURIPOTENT STEM CELLS, COMPRISING Oct4 IN COMBINATION WITH Bmi1 OR ITS UPSTREAM REGULATOR, AND METHOD FOR GENERATING INDUCED PLURIPOTENT STEM CELLS USING THE SAME
    Publication number: 20110159592
    Abstract: Disclosed is a composition for reprogramming somatic cells to generate embryonic stem cell-like cells, comprising: a) a Bmi1 (B cell-specific Moloney murine leukemia virus integration site 1) protein or a nucleic acid molecule coding for Bmi1; and b) an Oct4 protein or a nucleic acid molecule coding for Oct4. Also, a method is provided for reprogramming somatic cells to generate embryonic stem cell-like cells using the composition. In addition to reducing the number of the genetic factors conventionally needed, the composition and method allow the generation of pluripotent embryonic stem cell-like cells which have high potential in the cell therapy of various diseases.
    Type: Application
    Filed: October 15, 2010
    Publication date: June 30, 2011
    Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Seungkwon YOU, Jai-Hee MOON, Jun Sung KIM, Byung Sun YOON, Jung Han LEE, Eun Kyoung JUN, June Seok HEO
  • DE-DIFFERENTIATION OF ASTROCYTES INTO NEURAL STEM CELL USING NANOG
    Publication number: 20090246870
    Abstract: Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Nanog. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, or oligodendrocytes.
    Type: Application
    Filed: April 12, 2006
    Publication date: October 1, 2009
    Inventors: Seungkwon You, Jai Hee Moon, Byung Sun Yoon, Ki Dong Kim, Gyuman Park, Seung Jun Yoo, Eun Kyung Jun, Bona Kim, Sung Sik Kwak, Isaac Maeng
  • DE-DIFFERENTIATION OF ASTROCYTES INTO NEURAL STEM CELL USING Shh
    Publication number: 20090227023
    Abstract: Disclosed are a composition and a method for inducing the de-differentiation of astrocytes into neural stem cells using Shh. The de-differentiated neural stem cells have the ability to differentiate into astrocytes, neurons, and oligodendrocytes.
    Type: Application
    Filed: April 12, 2006
    Publication date: September 10, 2009
    Inventors: Seungkwon You, Jai Hee Moon, Byung Sun Yoon, Ki Dong Kim, Gyuman Park, Seung Jun Yoo, Eun Kyung Jun, Bona Kim, Sung Sik Kwak, Isaac Maeng
  • Use of passive myostatin immunization in egg laying vertebrates
    Patent number: 7488480
    Abstract: A method to alter the phenotype of animals, e.g., the progeny of egg laying vertebrates, which employs passive immunization, is provided.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: February 10, 2009
    Assignee: Regents of the University of Minnesota
    Inventors: Mohamed E. El Halawani, Seungkwon You
  • Myostatin immnoconjugate
    Patent number: 7037501
    Abstract: A method to alter the phenotype of animals, e.g., avians, which employs passive and active immunization is provided.
    Type: Grant
    Filed: January 4, 2001
    Date of Patent: May 2, 2006
    Assignee: Regents of the University of Minnesota
    Inventors: Mohamed E. El Halawani, Seungkwon You
  • Use of passive myostatin immunization
    Publication number: 20060088543
    Abstract: A method to alter the phenotype of animals, e.g., avians, which employs passive and active immunization is provided.
    Type: Application
    Filed: October 11, 2005
    Publication date: April 27, 2006
    Inventors: Mohamed El Halawani, Seungkwon You
  • Use of passive myostatin immunization
    Publication number: 20020127234
    Abstract: A method to alter the phenotype of animals, e.g., avians, which employs passive and active immunization is provided.
    Type: Application
    Filed: January 4, 2001
    Publication date: September 12, 2002
    Inventors: Mohamed E. El Halawani, Seungkwon You