Abstract: Systems and methods disclosed herein enable the characterization of material property distribution across a sample to ensure sample consistency and/or to detect and characterize anomalies including tumors, inclusions, cracks, changes in structural stiffness in samples capable to experience deformation. The boundary displacement data is collected using a plurality of induced deformations at a plurality of angles and locations relative to surfaces/boundaries of the sample, and the data is transformed to determine material properties of the sample using numerical techniques and material modeling.