Abstract: Disclosed herein are methods of making nanostructured metal-organic frameworks. The methods include contacting a homogenized ligand solution with a homogenized aqueous metal salt solution at room temperature to form a mixture; and agitating the mixture for an amount of time to thereby form the nanostructured metal-organic framework at room temperature; wherein the homogenized ligand solution comprises a ligand dispersed substantially homogenously in a solvent selected from the group consisting of water, ethanol, isopropanol, n-propanol, lactic acid, and combinations thereof; and wherein the homogenized aqueous metal salt solution comprises a metal salt dispersed substantially homogenously in an aqueous solvent. Also disclosed herein are nanostructured metal-organic frameworks made by the methods described herein.