Abstract: A pharmaceutical or neutraceutical composition for preventing or treating of chronic inflammation and concomitant biofilms in the gastrointestinal tract (GI tract). The multidimensional clinically tested composition accelerates intestinal epithelium recovery and it destabilises Gram-negative bacteria in their habitat, but it also eliminates their LPS molecules, which are highly allergenic. The synergistic composition contains a pharmaceutically effective amount of at least L-glutamine with zinc and vitamine A for recovery of the epithelium cells of the gastrointestinal tract, at least enzymes selected from the group of polysaccharidases, proteases, lipases and/or antioxidants, for decomposing a bio film that is present in the gut, at least one chelator for inorganic components such as iron and at least one binder for organic components originating from the decomposition of the biofilm and/or bacteria.