Patents by Inventor Seyedey-Faezeh Salehi-Amin

Seyedey-Faezeh Salehi-Amin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules to enhance P53 activity
    Patent number: 9737546
    Abstract: A method of enhancing p53 activity of a p53 mutant polypeptide is provided. The method includes interacting a compound to an open L1/S3 binding site of the p53 mutant polypeptide, where the p53 activity of the p53 mutant polypeptide is enhanced in the presence of the compound. Compounds were identified from databases of compounds for virtual drug screening. Methods of screening for compounds that enhance p53 activity by binding to the open L1/S3 binding site, and methods of treatment using the identified compounds, are also provided.
    Type: Grant
    Filed: August 9, 2014
    Date of Patent: August 22, 2017
    Assignee: The Regents of the University of California
    Inventors: Rommie E. Amaro, Roberta Baronio, Ozlem Demir, Peter Kaiser, Richard H. Lathrop, Seyedey-Faezeh Salehi-Amin, Christopher D. Wassman