Abstract: Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ?H>˜5?L, and pulse duration shorter than ?/4?L along HF beam. The phase between HF and LF pulses is ?Ltm for each group, where tm varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

Abstract: Estimation of vibration amplitude of intra-capillary micro-bubbles driven to vibrate with an incident ultrasound wave with amplitude and frequency to adjust the drive amplitude of the incident wave to obtain specified vibration amplitude of extra-capillary tissue. Estimation uses transmission of M groups of pulse complexes having low frequency pulse (LF) at bubble drive frequency, and high frequency (HF) pulse with angular frequency ?H> ~ 5 ?L, and pulse duration shorter than ?/4?L along HF beam. The phase between HF and LF pulses is ?Ltm for each group, where tm varies between the groups. Within each group, LF pulse varies between pulse complexes in amplitude and/or, where the LF pulse can be zero for a pulse complex, and LF pulse is different from zero for pulse complex within each group. HF receive signals are processed to obtain a parameter relating to bubble vibration amplitude when the HF pulse hits bubble.

Abstract: Increasing the immune response to a given cancer in a patient through increasing lymphatic flow out of the cancer region, following a primary action of the cancer that loads professional antigen-presenting cells/dendritic cells (APCs/DCs) with tumor-associated antigen (TAA) from the tumor into the interstitial fluid of the cancer region. Example primary actions are radio-therapy, both stereotactic and brachytherapy using implanted seeds, proton-therapy, and chemical- or radio-pharmaceutical therapy. Intra-capillary micro-bubbles in the tumor are brought to vibrate with incident ultrasound of appropriate frequency and amplitude, producing vibrations in the extra capillary tissue that produces an outward acoustic radiation force and micro shear waves in the tissue that increases transport of the interstitial fluid.