Abstract: A device and method for locally and directionally marking the surface of the skin where a diagnostic or therapeutic procedure is to be performed utilizing a hand-held marking device comprising a supporting body having one or more thin-edged, tapered patterning elements extending in relief therefrom. The patterning elements are impressed into the skin to produce temporary directional and positioning markings capable of delineating a selected target site. The area is then rendered antiseptic and the desired procedure is carried out using the directional and positional guidance afforded by the markings.