Patents by Inventor Sezin ADAY

Sezin ADAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOPARTICLE FORMULATIONS AND METHODS OF THEIR USE
    Publication number: 20220031630
    Abstract: Disclosed are pharmaceutical compositions formulated for delivery to the brain of a subject. The compositions include a plurality of nanoparticles (NPs) containing a brain therapeutic agent, poly(lactic-co-glycolic acid) (PLGA), and a pharmaceutically acceptable excipient selected from the group consisting of a surfactant, peptide, and combinations thereof. Also disclosed are methods of their use.
    Type: Application
    Filed: September 13, 2019
    Publication date: February 3, 2022
    Inventors: Jeffrey M. KARP, Wen LI, Nitin JOSHI, Robert S. LANGER, Rebekah MANNIX, Jianhua QIU, Sezin ADAY
  • HUMAN BLOOD-BRAIN BARRIER MODEL DERIVED FROM STEM CELLS
    Publication number: 20210380938
    Abstract: The present disclosure relates to a method for obtaining human brain-like endothelial cells by contacting a population of cells isolated from stem cells with a differentiation medium to obtain endothelial cells and co-culturing said endothelial cells with pericytes, with cells of the neurovascular unit or with a pericytes conditioned medium, to obtain brain-like endothelial cells. The present disclosure also relates to the use of the brain-like endothelial cells as an in vitro model of human blood-brain barrier and a kit for measuring blood-brain barrier permeability of a substance, comprising in vitro human endothelial cells.
    Type: Application
    Filed: June 11, 2021
    Publication date: December 9, 2021
    Inventors: Lino DA SILVA FERREIRA, Emmanuel Bernard SEVIN, Roméo Paul CECCHELLI, Sezin ADAY
  • A HUMAN BLOOD-BRAIN BARRIER MODEL DERIVED FROM STEM CELLS
    Publication number: 20160040125
    Abstract: The present disclosure relates to a method for obtaining human brain-like endothelial cells by contacting a population of cells isolated from stem cells with a differentiation medium to obtain endothelial cells and co-culturing said endothelial cells with pericytes, with cells of the neurovascular unit or with a pericytes conditioned medium, to obtain brain-like endothelial cells. The present disclosure also relates to the use of the brain-like endothelial cells as an in vitro model of human blood-brain barrier and a kit for measuring blood-brain barrier permeability of a substance, comprising in vitro human endothelial cells.
    Type: Application
    Filed: March 26, 2014
    Publication date: February 11, 2016
    Inventors: Lino DA SILVA FERREIRA, Emmanuel Bernard SEVIN, Roméo Paul CECCHELLI, Sezin ADAY