Abstract: Undergarments, such as panties and pantyhose, having a highly-ventilated crotch panel which has one or more apertures therein in order to provide adequate light and ventilation to prevent the conditions that are favorable to vaginitis or other infections. The openness of the crotch panel enhances air flow, allows for the dissipation of heat and moisture, and yet, is not so large as to cause binding, discomfort, or an uncomfortable feeling of exposure to the wearer. In some embodiments, moisture is further absorbed or dissipated around the aperture(s) by a surrounding trim, such as elasticized lace, which also provides the illusion of covering to the wearer. In other embodiments, the aperture(s) have a modesty panel which is a single layer of an open-weave knit mesh.