Patents by Inventor Sha ZHOU

Sha ZHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • P450 Cytochrome Enzyme for Andrographolide Synthesis and Its Application
    Publication number: 20240117387
    Abstract: The present disclosure provides a P450 cytochrome enzyme for andrographolide synthesis and its application, belonging to the field of bioengineering. The present disclosure uses Saccharomyces cerevisiae CEN.PK2-1D as a host, and implements knockout of ROX1 and GAL80 genes on the genome, and integrative expression of GGPP synthase encoding gene and CPS diterpene synthase encoding gene at ROX1 site; and implements free expression of ApCPR and CYP71A8 and CYP71D10 both with truncated signal peptides, successfully constructing recombinant S. cerevisiae, and achieving de novo synthesis of 3,15,19-Trihydroxy-8(17),13-ent-labdadiene-16-oic acid. Compared with the blank, a response value of a product peak reaches 1.9*106, and this strategy provides necessary reference for analyzing biosynthetic pathway of andrographolide and using metabolic engineering to synthesize andrographolide and related derivatives thereof.
    Type: Application
    Filed: December 15, 2023
    Publication date: April 11, 2024
    Inventors: Jingwen Zhou, Shan Li, Song Gao, Sha Xu, Weizhu Zeng, Shiqin Yu
  • having highly efficient gene transfer ability to plant imparted thereto
    Patent number: 9944936
    Abstract: The present invention relates to an Agrobacterium having improved gene transfer efficiency. The present invention provides a transformed Agrobacterium which harbors a foreign GABA transaminase gene and exhibits improved gene transfer efficiency, and a method for producing a transformed plant using the same.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: April 17, 2018
    Assignee: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi Ezura, Koji Nakamura, Satoko Nonaka, Tatsuhiko Someya, Sha Zhou
  • AGROBACTERIUM HAVING HIGHLY EFFICIENT GENE TRANSFER ABILITY TO PLANT IMPARTED THERETO
    Publication number: 20150368658
    Abstract: The present invention relates to an Agrobacterium having improved gene transfer efficiency. The present invention provides a transformed Agrobacterium which harbors a foreign GABA transaminase gene and exhibits improved gene transfer efficiency, and a method for producing a transformed plant using the same.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 24, 2015
    Applicant: UNIVERSITY OF TSUKUBA
    Inventors: Hiroshi EZURA, Koji NAKAMURA, Satoko NONAKA, Tatsuhiko SOMEYA, Sha ZHOU
  • MALDI analysis using modified matrices with affinity groups for non-covalent binding with analytes
    Patent number: 8119416
    Abstract: Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry. The method uses photon energy absorbing molecules that can bind with analyte either temporarily or permanently to improve the desorption and ionization of analyte. The photon energy absorbing molecules can be positively charged or negatively charged.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: February 21, 2012
    Assignee: Wuxi WeiYi Zhinengkeji, Inc.
    Inventors: Tianxin Wang, Qun Liu, Sha Zhou Zou
  • Methods and compositions for mass spectrometry analysis
    Publication number: 20090269855
    Abstract: Methods and compounds are provided to improve the desorption and ionization of analyte for mass spectrometry analysis. More specifically, it is for laser desorption/ionization mass spectrometry. The method uses photon energy absorbing molecules that can bind with analyte either temporarily or permanently to improve the desorption and ionization of analyte. The photon energy absorbing molecules can be positively charged or negatively charged.
    Type: Application
    Filed: June 23, 2009
    Publication date: October 29, 2009
    Inventors: Tiaxin Wang, Qun Liu, Sha Zhou Zou