Abstract: A centimeter-resolution integrated photonic millimeter-wave (mmWave) radar chip operating in the mmWave V band based on a 4-inch wafer-scale thin-film lithium niobate (TFLN) technology is provided. The fabricated TFLN photonic mmWave integrated circuit has a first electro-optic modulator (EOM) capable of generating a broadband linear frequency modulated mmWave radar waveform through optical frequency multiplication of a low-frequency input signal, and a second EOM for frequency de-chirp of the reflected echo wave, thereby greatly relieving bandwidth requirements for the digital-to-analog converter in the transmitter and analog-to-digital converter in the receiver. In the absence of optical and electrical filters, the radar chip features continuous on-demand tunability of the center frequency and bandwidth, currently only limited by the bandwidths of electrical amplifiers.

Abstract: The application relates to fluorescence-quenched substrates of Formula (I) for an acid ?-glucosidase (GCase) and their use in a method for determining GCase activity in a cell or tissue, a method for localizing GCase activity within a cell, a method for determining the effect of a GCase modulator in a cell, a method for determining the efficacy if a GCase-directed therapy, and a method of screening for a GCase activity enhancer.

Abstract: Methods for analysis of the magnetic grain using a software program effectively and accurately by improving the magnetic grain boundary contrast from an image prior to analyzing the grain size with an imaging analysis program. A method for automated grain size analysis includes obtaining a SEM electronic image of a magnetic material composed of a plurality of grains and modifying the image by smoothing the image, removing high spatial and low spatial frequencies from the image, improving contrast of the image, pixelating the image, processing the image to a binary image, and clearing outer edges of the binary image to remove at least incomplete grains to generate grain size data from the image.

Abstract: The present disclosure relates to methods of manufacturing at least a portion of a magnetic layer of a magnetic recording disk. The methods include forming a plurality of sacrificial, discrete structures via imprint lithography. The sacrificial, discrete structures are used to form a plurality of three-dimensional segregant structures in a magnetic layer of the magnetic recording disk. The present disclosure also relates to corresponding magnetic recording disks.

Abstract: Aspects of the disclosure relate to isolated nucleic acids encoding one or more inhibitory nucleic acids. In some embodiments, the inhibitory nucleic acids are microRNAs (miRNAs) or artificial microRNAs (amiRNAs). The inhibitory nucleic acids may target one or more genes involved in cytochrome p450 toxicity, for example Slc16a2, Acls5, and Cyb5b. In some embodiments, an inhibitory nucleic acid is a miR-375. The disclosure relates, in some aspects, to methods of reducing cytochrome p450-related toxicity in a cell (e.g., a liver cell) by administering the isolated nucleic acids of the disclosure.

Abstract: Provided herein are therapeutic methods for the treatment of exacerbations of inflammatory respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and asthma. In particular, the invention provides methods for patient selection, diagnosis, and treatment. Also provided herein are methods for preparing and analyzing lysophosphatidic acid (LPA) samples.

Abstract: The present disclosure relates to methods of manufacturing at least a portion of a magnetic layer of a magnetic recording disk. The methods include forming a plurality of sacrificial, discrete structures via imprint lithography. The sacrificial, discrete structures are used to form a plurality of three-dimensional segregant structures in a magnetic layer of the magnetic recording disk. The present disclosure also relates to corresponding magnetic recording disks.

Abstract: Methods for analysis of the magnetic grain using a software program effectively and accurately by improving the magnetic grain boundary contrast from an image prior to analyzing the grain size with an imaging analysis program. A method for automated grain size analysis includes obtaining a SEM electronic image of a magnetic material composed of a plurality of grains and modifying the image by smoothing the image, removing high spatial and low spatial frequencies from the image, improving contrast of the image, pixelating the image, processing the image to a binary image, and clearing outer edges of the binary image to remove at least incomplete grains to generate grain size data from the image.

Abstract: An elastic electrical contact includes a base, a connecting member extending from an end of the base, and a resisting member extending from an end of the connecting member configured for resisting against an electronic element. The base includes a bottom surface being soldered to a circuit board and a top surface, and defines a through hole and a portion of tin between the bottom surface and the circuit board. When soldering to the circuit board, tin can extend through the through hole.

Abstract: A semiconductor device having a ferroelectric capacitor is formed by the steps of forming a lower electrode on a substrate, applying a rapid thermal annealing process to the lower electrode, depositing, after the step of rapid thermal annealing process, a ferroelectric film on the lower electrode, crystallizing the ferroelectric film by applying a thermal annealing process to the ferroelectric film, and forming an upper electrode on the ferroelectric insulation film.