Abstract: Described herein is a sensor comprising a doped silicon layer, a graphene layer on the doped silicon layer, a molecularly imprinted polymer (MIP) layer on the graphene layer, and electrodes in operative arrangement with the MIP layer and configured to provide a signal indicative of resistance. The MIP layer is derived from a MIP monomer and functional monomer. Also described herein is a detector comprising a sensor described herein as well as methods of making and using the sensors and detectors, e.g., to detect an analyte, such as a virus.

Abstract: Devices and methods for the detection of an analyte, e.g, from exhaled breath or air are provided. A sensor includes a polymer layer molecularly imprinted for the analyte, a metal layer, and an electrocatalytic layer disposed between the polymer layer and the metal layer. The electrocatalytic layer is functionalized with at least one chemical compound that provides for noncovalent interaction with the analyte. The sensor further includes electrodes in operative arrangement with the polymer layer and configured to provide a signal indicative of a resistance. A change in resistance of the device can indicate the presence of the analyte in the sample.

Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.

Abstract: Provided herein are devices (e.g., electrochemical sensors useful for detecting volatile organic compounds associated with certain diseases or conditions and/or diagnosing certain diseases or conditions). The devices comprise one or more layers of metal on a layer of silicon, and a layer of molecularly imprinted polymer in electrical communication with the one or more layers of metal, wherein the one or more layers of metal are each independently selected from a layer of chromium, platinum, gold, nickel, cobalt, tungsten, rhodium, iridium, silver, tin, titanium or tantalum, or an alloy thereof. Methods of using the devices (e.g., to detect one or more analytes in a sample, to detect and/or diagnose a disease or condition in a subject), and methods of making the devices are also provided.