Patents by Inventor Shadmehr Demehri

Shadmehr Demehri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T CELL-DIRECTED ANTI-CANCER VACCINES AGAINST COMMENSAL VIRUSES FOR TREATING MUCOSAL CARCINOMAS
    Publication number: 20240100141
    Abstract: Immune-based approaches to treat and reduce the risk of cancer of mucosal tissues by boosting T cell immunity against commensal HPVs.
    Type: Application
    Filed: January 21, 2022
    Publication date: March 28, 2024
    Inventor: Shadmehr Demehri
  • INTERLEUKIN 33 (IL-33) INHIBITION FOR TREATMENT OF CANCER, FIBROSIS AND INFLAMMATION
    Publication number: 20230255954
    Abstract: Described herein are methods and compositions for treating cancer, fibrosis, and inflammation, and reducing risk of developing cancer, fibrosis, and inflammation, using small molecule inhibitors of IL-33, i.e., pitavastatin calcium, tropisetron, ammonium glycyrrhizinate, ticagrelor, and cetrimonium bromide.
    Type: Application
    Filed: July 7, 2021
    Publication date: August 17, 2023
    Inventors: Shadmehr Demehri, Jong Ho Park
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20230026855
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: September 16, 2022
    Publication date: January 26, 2023
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 11478549
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: October 25, 2022
    Assignee: Washington University
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • T Cell-Directed Anti-Cancer Vaccines Against Commensal Viruses
    Publication number: 20220001004
    Abstract: Immune-based approaches to treat and prevent skin cancer by boosting T cell immunity against commensal HPVs present on skin. Thus, provided herein are compositions comprising: (i) a plurality of antigenic peptides each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses, (ii) a plurality of live or live attenuated commensal human papilloma viruses, (iii) a plurality of antigenic proteins from commensal human papilloma viruses, preferably in virus-like particles, and/or (iv) a plurality of nucleic acids encoding (a) a plurality of antigenic peptides, each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses or (b) a plurality of antigenic proteins from commensal human papilloma viruses; and optionally a T cell adjuvant that increases T cell response to the antigenic peptides.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 6, 2022
    Inventor: Shadmehr Demehri
  • COMPOSITIONS AND METHODS FOR LOCAL DELIVERY OF PHARMACEUTICAL AGENTS TO TREAT CANCER
    Publication number: 20210177831
    Abstract: Described herein are compositions comprising a T cell/thymic stromal lymphopoietin (TSLP) activating agent and an innate immunity activating agent, an methods of use thereof to treat cancer, e.g., cutaneous malignancies.
    Type: Application
    Filed: July 2, 2019
    Publication date: June 17, 2021
    Inventor: Shadmehr Demehri
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20210128732
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: January 4, 2021
    Publication date: May 6, 2021
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 10905763
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 2, 2021
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • COMPOSITIONS AND METHODS FOR TREATMENT OF PRE-CANCEROUS SKIN LESIONS
    Publication number: 20170246299
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Application
    Filed: September 10, 2015
    Publication date: August 31, 2017
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan