Patents by Inventor Shady Saeed
Shady Saeed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8357807Abstract: The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate. The isoquinolinium compounds of the present invention can be obtained in the form of solids, which can be purified using simple techniques and can be used to afford pure cisatracurium besylate without HPLC purification.Type: GrantFiled: May 1, 2008Date of Patent: January 22, 2013Assignee: CHEMAGIS Ltd.Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
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Patent number: 8293912Abstract: The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g.Type: GrantFiled: May 1, 2008Date of Patent: October 23, 2012Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
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Publication number: 20110185796Abstract: The present invention provides compounds which are useful, e.g., as reference markers for analyzing the purity of cisatracurium and salts thereof, a test method for determining the said purity and processes for preparing reference markers.Type: ApplicationFiled: April 28, 2009Publication date: August 4, 2011Applicant: CHEMAGIS Ltd.Inventors: Oded Arad, Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Lior Shahar, Vitaly Shteinman
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Patent number: 7943771Abstract: Provided is a process for producing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod), which includes reacting 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline with a non-gaseous amine precursor. Also provided are methods for isolating highly pure imiquimod. Further provided are intermediates useful in the production of imiquimod, methods for producing such intermediates, and methods for obtaining imiquimod from such intermediates.Type: GrantFiled: January 24, 2007Date of Patent: May 17, 2011Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Stephen Cherkez, Oded Arad
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Publication number: 20100256381Abstract: The present invention provides a process of producing cisatracurium compounds, e.g., cisatracurium besylate, from isoquinolinium salts of the structural formula (VIIA) wherein X? is an anion and R is H or a C1-C6 alkyl, or an activated form of the carboxylic acid with 1,5-pentanediol to form a cisatracurium salt, optionally via an intermediate compound (VIII). The cisatracurium compounds can be purified using simple techniques to afford pure cisatracurium besylate without the need for HPLC purification.Type: ApplicationFiled: May 1, 2008Publication date: October 7, 2010Applicant: CHEMAGIS LTD.Inventors: Oded Arad, Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Ofer Sharon
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Publication number: 20100184988Abstract: The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g.Type: ApplicationFiled: May 1, 2008Publication date: July 22, 2010Applicant: CHEMAGIS LTD.Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
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Publication number: 20100168431Abstract: The present invention provides novel isoquinolinium compounds, methods of producing the isoquinolinium compounds, and methods for converting them into cisatracurium, e.g., cisatracurium besylate.Type: ApplicationFiled: May 1, 2008Publication date: July 1, 2010Applicant: Chemagis Ltd.Inventors: Vladimir Naddaka, Shen Jingshan, Oded Arad, Guo Hongli, Ofer Sharon, Eyal Klopfer, Shady Saeed
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Patent number: 7745471Abstract: Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates from the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.Type: GrantFiled: June 16, 2005Date of Patent: June 29, 2010Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Oded Arad, Joseph Kaspi
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Patent number: 7659398Abstract: The present invention provides a process for preparing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod). The process preferably includes heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with ammonia in a polar aprotic solvent at relatively moderate pressure to produce imiquimod, and optionally purifying the imiquimod. The process of the present invention can produce highly pure imiquimod in high yield.Type: GrantFiled: February 14, 2007Date of Patent: February 9, 2010Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Shady Saeed, Stephen Cherkez, Oded Arad
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Publication number: 20090221811Abstract: The present invention provides processes for preparing intermediates useful in the preparation of gemcitabine and other nucleosides, and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts. Also provided is a process for selectively isolating the D-erythro and D-threo isomers of D-erythro and D-threo isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)-propionic acid salts, and processes for using such isomers in the preparation of nucleoside analogs such as, e.g., gemcitabine, intermediates thereof, and analogs thereof.Type: ApplicationFiled: April 27, 2009Publication date: September 3, 2009Applicant: CHEMAGIS LTD.Inventors: Vladimir NADDAKA, Eyal KLOPFER, Shady SAEED, Dionne MONTVILISKY, Oded ARAD, Joseph KASPI
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Patent number: 7524960Abstract: A novel process for preparing highly pure cilostazol, effected by reacting 6-hydroxy-3,4-dihydroquinolinone and 5-(4-chlorobutyl)-1-cyclohexyl-1H-tetrazole in the presence of a hydrated inorganic base, is disclosed. Further disclosed is highly pure cilostazol, and particularly highly pure cilostazol that is substantially free of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butyl ]-3,4-dihydro-1H-quinolin-2-one.Type: GrantFiled: March 16, 2005Date of Patent: April 28, 2009Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Guy Davidi, Shady Saeed, Oded Arad, Joseph Kaspi
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Publication number: 20080194822Abstract: The present invention provides a process for preparing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod). The process preferably includes heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with ammonia in a polar aprotic solvent at relatively moderate pressure to produce imiquimod, and optionally purifying the imiquimod. The process of the present invention can produce highly pure imiquimod in high yield.Type: ApplicationFiled: February 14, 2007Publication date: August 14, 2008Applicant: CHEMAGIS LTD.Inventors: Vladimir Naddaka, Shady Saeed, Stephen Cherkez, Oded Arad
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Publication number: 20080177074Abstract: Provided is a process for producing highly pure 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (imiquimod), which includes reacting 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline with a non-gaseous amine precursor. Also provided are methods for isolating highly pure imiquimod. Further provided are intermediates useful in the production of imiquimod, methods for producing such intermediates, and methods for obtaining imiquimod from such intermediates.Type: ApplicationFiled: January 24, 2007Publication date: July 24, 2008Applicant: CHEMAGIS LTD.Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Stephen Cherkez, Oded Arad
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Patent number: 7323568Abstract: The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I). The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with bubbling of gaseous ammonia to afford Imiquimod of formula (I). According to the present invention, by using this process and novel purification methods, essentially as described herein, highly pure Imiquimod is obtained.Type: GrantFiled: December 12, 2005Date of Patent: January 29, 2008Assignee: Chemagis Ltd.Inventors: Vladimir Naddaka, Shady Saeed, Dionne Montviliski, Lior Zelikovitch, Oded Arad, Joseph Kaspi
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Publication number: 20070249823Abstract: The present invention provides novel intermediates, which preferably include 3-substituted, alkyl 2,2-difluoro-3-hydroxy-3-(2,2-dialkyldioxolan-4-yl)-propionate derivatives, and 3,5-disubstituted-2-deoxy-2,2-difluoro-1-oxo-D-ribose derivatives. The present invention also provides processes for producing such intermediates and processes for producing gemcitabine therewith.Type: ApplicationFiled: April 6, 2007Publication date: October 25, 2007Applicant: Chemagis Ltd.Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Dionne Montvilisky, Oded Arad, Joseph Kaspi
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Publication number: 20070191598Abstract: The present invention provides processes for preparing novel chemical substances that are useful as intermediates in the preparation of gemcitabine and processes for preparing gemcitabine therewith. Exemplary intermediates include mixtures of D-erythro and D-threo (3R- and 3S-) isomers of 3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionic acid salts. Also provided is a novel process for selectively isolating the D-erythro and D-threo isomers of the said salts in purities of at least about 95%, and processes of using them for preparing nucleoside analogs such as, e.g., gemcitabine and intermediates and analogs thereof.Type: ApplicationFiled: January 30, 2007Publication date: August 16, 2007Applicant: CHEMAGIS LTD.Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Dionne Montvilisky, Oded Arad, Joseph Kaspi
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Publication number: 20070135640Abstract: The present invention provides a process for preparing 4-amino-1-isobutyl-1H-imidazo[4,5-c]quinoline (Imiquimod) of formula (I). The process comprises heating 4-chloro-1-isobutyl-1H-imidazo[4,5-c]quinoline of formula (II) with formamide, and optionally with bubbling of gaseous ammonia to afford Imiquimod of formula (I). According to the present invention, by using this process and novel purification methods, essentially as described herein, highly pure Imiquimod is obtained.Type: ApplicationFiled: December 12, 2005Publication date: June 14, 2007Applicant: Chemagis Ltd.Inventors: Vladimir Naddaka, Shady Saeed, Dionne Montviliski, Lior Zelikovitch, Oded Arad, Joseph Kaspi
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Publication number: 20060014814Abstract: Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates fro the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.Type: ApplicationFiled: June 16, 2005Publication date: January 19, 2006Inventors: Vladimir Naddaka, Eyal Klopfer, Shady Saeed, Oded Arad, Joseph Kaspi
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Publication number: 20050222202Abstract: A novel process for preparing highly pure cilostazol, effected by reacting 6-hydroxy-3,4-dihydroquinolinone and 5-(4-chlorobutyl)-1-cyclohexyl-1H-tetrazole in the presence of a hydrated inorganic base, is disclosed. Further disclosed is highly pure cilostazol, and particularly highly pure cilostazol that is substantially free of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1-[4-(1-cyclohexyl-1H-tetrazol-5-yl)-butyl]-3,4-dihydro-1H-quinolin-2-one.Type: ApplicationFiled: March 16, 2005Publication date: October 6, 2005Inventors: Vladimir Naddaka, Guy Davidi, Shady Saeed, Oded Arad, Joseph Kaspi