Patents by Inventor Shafiqul I. Chowdhury

Shafiqul I. Chowdhury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11083787
    Abstract: The application describes recombinant BoHV-1 triple mutant viruses that express protective antigens of other bovine respiratory viruses associated with Bovine respiratory disease complex (BRDC).
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: August 10, 2021
    Assignee: Board of Supervisors of the Louisiana State University and Agricultural and Mechanical College
    Inventor: Shafiqul I. Chowdhury
  • Patent number: 10690669
    Abstract: Methods, compositions, devices, and kits are described herein that are useful for detecting BoHV-1 infection in animals and/or for distinguishing animals that may benefit from administration of BoHV-1 tmv vaccine.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: June 23, 2020
    Assignee: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventor: Shafiqul I. Chowdhury
  • Publication number: 20180353596
    Abstract: The application describes recombinant BoHV-1 triple mutant viruses that express protective antigens of other bovine respiratory viruses associated with Bovine respiratory disease complex (BRDC).
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Applicant: THE BOARD OF SUPERVISORS OF THE LOUISIANA STATE UN IVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
    Inventor: Shafiqul I. Chowdhury
  • Patent number: 8877211
    Abstract: A BHV-1 mutant virus has been made that incorporates into a single virus two or more deletions in one or more of three genes—glycoprotein N, glycoprotein E and Us9. Specifically, a BHV-1 UL49.5?30-32 CT-null virus was made and tested. This mutant virus was then used to incorporate additional changes, e.g., the glycoprotein E cytoplasmic-tail deletion, the Us9 deletion, or both. This triple mutant BHV-1 UL49.5?30-32 CT-null/gE CT?/Us9? virus will be superior to the current BHV-1 mutants because the mutant virus will not be shed following reactivation, will be a DIVA based on gE CT-specific serum antibodies, and will induce better protective response by inducing higher SN titers and better cellular immune response. This new virus will have sufficient viral replication in the nasal epithelium and will be a good vaccine for protection of cattle from BHV-1. The new mutant viruses can also be used as vectors for exogenous genes.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: November 4, 2014
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Shafiqul I. Chowdhury, Hui Yong Wei
  • Publication number: 20130034585
    Abstract: A BHV-1 mutant virus has been made that incorporates into a single virus two or more deletions in one or more of three genes—glycoprotein N, glycoprotein E and Us9. Specifically, a BHV-1 UL49.5?30-32 CT-null virus was made and tested. This mutant virus was then used to incorporate additional changes, e.g., the glycoprotein E cytoplasmic-tail deletion, the Us9 deletion, or both. This triple mutant BHV-1 UL49.5?30-32 CT-null/gE CT?/Us9? virus will be superior to the current BHV-1 mutants because the mutant virus will not be shed following reactivation, will be a DIVA based on gE CT-specific serum antibodies, and will induce better protective response by inducing higher SN titers and better cellular immune response. This new virus will have sufficient viral replication in the nasal epithelium and will be a good vaccine for protection of cattle from BHV-1. The new mutant viruses can also be used as vectors for exogenous genes.
    Type: Application
    Filed: December 14, 2011
    Publication date: February 7, 2013
    Inventors: SHAFIQUL I. CHOWDHURY, HUI YONG WEI
  • Patent number: 6284251
    Abstract: A safe live recombinant virus as well as a vaccine is produced by the deletion of a portion of the native glycoprotein E (gE) coding region of bovine herpesvirus 1 (BHV-1) followed by the insertion of a plasmid including a foreign functional &bgr;-gal at the gE locus. The deletion of gE gene stably attenuates the virus and serves as an immunological marker differentiating vaccinated animals from infected animals. Moreover, production of &bgr;-gal allows easy assessment of gE&Dgr;3.1IBR&bgr; virus replication in vaccinated animals and serves as a phenotypic marker which distinguishes it from wild type virus replication in infected animals.
    Type: Grant
    Filed: January 29, 1999
    Date of Patent: September 4, 2001
    Assignee: Kansas State University Research Foundation
    Inventor: Shafiqul I. Chowdhury
  • Patent number: 6221360
    Abstract: The disclosed invention is directed to (1) recombinant bovine herpesvirus genes having foreign genes inserted therein, (2) infectious recombinant bovine herpesviruses carrying these recombinant genes, (3) methods of producing these recombinant bovine herpesviruses, (4) methods of immunizing animals against diseases caused by bovine herpesviruses using these recombinant bovine herpesviruses as vaccines, and (5) methods of detecting infection of an animal by these recombinant bovine herpesviruses. In its preferred form, the invention is directed to the construction of an infectious recombinant bovine herpesvirus type 1 having a functional &bgr;-galactosidase gene inserted in and thereby inactivating the thymidine kinase gene (e.g., Gal-TK); infection of an animal with the resultant avirulent vaccine virus is detected by assaying the animal's respiratory secretions for the presence of virus having &bgr;-galactosidase activity in host cells.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: April 24, 2001
    Assignee: Kansas State University Research Foundation
    Inventor: Shafiqul I. Chowdhury